Literature associating USP18 and chromosome 22q11.2 microduplication syndrome
ISG15-specific-processing protease; Involved in the regulation of inflammatory response to interferon type 1. Can efficiently cleave only ISG15 fusions including native ISG15 conjugates linked via isopeptide bonds. Necessary to maintain a critical cellular balance of ISG15-conjugated proteins in both healthy and stressed organisms; Ubiquitin specific peptidases
Synonyms: USP18, USP18p, hUSP18, Q9UMW8, ISG43 ...