DISEASES

Disease-gene associations mined from literature

Literature associating OSM and obstructive nephropathy

OSM [ENSP00000215781]

Oncostatin M; Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (By similarity).

Synonyms:  OSM,  B5BUQ7,  B5MC70,  B5MCX1,  OSM-001 ...

Linkouts:  STRING  Pharos  UniProt  OMIM