DISEASES

Disease-gene associations mined from literature

Literature associating TRMT6 and thiamine-responsive megaloblastic anemia syndrome

TRMT6 [ENSP00000203001]

mRNA methyladenosine-N(1)-methyltransferase non-catalytic subunit TRM6; Substrate-binding subunit of tRNA (adenine-N(1)-)- methyltransferase, which catalyzes the formation of N(1)- methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. Together with the TRMT61A catalytic subunit, part of a mRNA N(1)-methyltransferase complex that mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries.

Synonyms:  TRMT6,  TRMT6p,  hTRMT6,  Q9UJA5,  TRMT6-001 ...

Linkouts:  STRING  Pharos  UniProt