DISEASES

Disease-gene associations mined from literature

Literature associating ITGB4 and Kindler syndrome

ITGB4 [ENSP00000200181]

Integrin, beta 4; Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling.

Synonyms:  ITGB4,  ITGB4p,  hITGB4,  A0A024R8K7,  A0A024R8T0 ...

Linkouts:  STRING  Pharos  UniProt  OMIM