Disease-gene associations mined from literature

Literature associating TARBP1 and thiamine-responsive megaloblastic anemia syndrome

TARBP1 [ENSP00000040877]

TAR RNA-binding protein of 185 kDa; Probable S-adenosyl-L-methionine-dependent methyltransferase which methylates RNA molecules such as tRNAs. In case of infection by HIV-1, it binds to the loop region of TAR RNA, a region also bound by RNA polymerase II. Binding of TARBP1 and RNA polymerase II to HIV-1 TAR RNA is mutually exclusive, suggesting that TARBP1 may function alone or in conjunction with HIV-1 Tat to disengage RNA polymerase II from HIV-1 TAR RNA. May act by methylating HIV-1 TAR RNA; Armadillo-like helical domain containing

Synonyms:  TARBP1,  TARBP1p,  hTARBP1,  Q13395,  TARBP1-001 ...

Linkouts:  STRING  Pharos  UniProt  OMIM