DISEASES

Disease-gene associations mined from literature

Literature associating ITGA3 and focal segmental glomerulosclerosis

ITGA3 [ENSP00000007722]

Integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor); Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha- 3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration; CD molecules

Synonyms:  ITGA3,  ITGA3p,  hITGA3,  B4E0H8,  D6R9X8 ...

Linkouts:  STRING  Pharos  UniProt  OMIM