Literature associating HS3ST1 and hereditary spherocytosis
Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 1; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site.
Synonyms: HS3ST1, HS3ST1p, hHS3ST1, A0A024R9R4, E9PDE3 ...