DISEASES

Disease-gene associations mined from literature

CYREN disease associations

CYREN [ENSP00000376823]

Cell cycle regulator of non-homologous end joining; [Isoform 1]: Cell-cycle-specific inhibitor of classical non- homologous end joining (NHEJ) of DNA double-strand break (DSB) repair during the S and G2 phases . Acts as a regulator of DNA repair pathway choice by specifically inhibiting classical NHEJ during the S and G2 phases, thereby promoting error-free repair by homologous recombination during cell cycle phases when sister chromatids are present . Preferentially protects single-stranded overhangs at break sites by inhibiting classical NHEJ, thereby creating a local environment that favors homologous recombination . Acts via interaction with XRCC5/Ku80 and XRCC6/Ku70, interaction restricted during the S and G2 phases only . Molecular mechanisms governing classical NHEJ inhibition via interaction with XRCC5/Ku80 and XRCC6/Ku70 are unknown . May act as a regulator of proteasome (By similarity).

Synonyms:  CYREN,  C9JKC7,  Q9BWK5,  C9JKC7p,  hC9JKC7 ...

Linkouts:  STRING  Pharos  UniProt