DISEASES

Disease-gene associations mined from literature

CNDP2 disease associations

CNDP2 [ENSP00000325548]

Cytosolic non-specific dipeptidase; Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly . Acts as a functional tumor suppressor in gastric cancer via activation of the mitogen-activated protein kinase (MAPK) pathway. An elevated level of CNDP2 activates the p38 and JNK MAPK pathways to induce cell apoptosis, and a lower level of CNDP2 activates the ERK MAPK pathway to promote cell proliferation . Isoform 2 may play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells . Catalyzes the production of N-lactoyl-amino acids from lactate and amino acids by reverse proteolysis .

Synonyms:  CNDP2,  CNDP2p,  hCNDP2,  A0A087WVS2,  A0A087WYZ1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM