DISEASES

Disease-gene associations mined from literature

RHBDF2 disease associations

RHBDF2 [ENSP00000322775]

Inactive rhomboid protein 2; Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. ; Belongs to the peptidase S54 family.

Synonyms:  RHBDF2,  RHBDF2p,  hRHBDF2,  K7EIY3,  K7EJ10 ...

Linkouts:  STRING  Pharos  UniProt  OMIM