DISEASES

Disease-gene associations mined from literature

NPEPPS disease associations

NPEPPS [ENSP00000320324]

Puromycin-sensitive aminopeptidase; Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain. ECO:0000269|PubMed:17154549, ECO:0000269|PubMed:17318184,

Synonyms:  NPEPPS,  E9PI82,  E9PJ74,  E9PJF9,  E9PJY4 ...

Linkouts:  STRING  Pharos  UniProt  OMIM