DISEASES

Disease-gene associations mined from literature

CES3 disease associations

CES3 [ENSP00000304782]

Carboxylesterase 3; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)-1-piperidino]- carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics.

Synonyms:  CES3,  CES3p,  hCES3,  A0A0C4DFY7,  H3BRE5 ...

Linkouts:  STRING  Pharos  UniProt  OMIM