DISEASES

Disease-gene associations mined from literature

ACE disease associations

ACE [ENSP00000290866]

Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety; Belongs to the peptidase M2 family.

Synonyms:  ACE,  A0A0A0MSN4,  J3KRH5,  J3KS28,  J3KSQ5 ...

Linkouts:  STRING  Pharos  UniProt  OMIM