DISEASES

Disease-gene associations mined from literature

KLF10 disease associations

KLF10 [ENSP00000285407]

Krueppel-like factor 10; Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis (By similarity). May play a role in the cell cycle regulation. ; Belongs to the Sp1 C2H2-type zinc-finger protein family.

Synonyms:  KLF10,  KLF10p,  hKLF10,  Q13118,  Q13118p ...

Linkouts:  STRING  Pharos  UniProt  OMIM