DISEASES

Disease-gene associations mined from literature

FGD5 disease associations

FGD5 [ENSP00000285046]

FYVE, RhoGEF and PH domain-containing protein 5; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF- induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape.

Synonyms:  FGD5,  FGD5p,  hFGD5,  A0A1W2PRG7,  A0A2X0SFF2 ...

Linkouts:  STRING  Pharos  UniProt  OMIM