DISEASES

Disease-gene associations mined from literature

RAD18 disease associations

RAD18 [ENSP00000264926]

E3 ubiquitin-protein ligase RAD18; E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap- filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA- associated PCNA on 'Lys-164'. Has ssDNA binding activity.

Synonyms:  RAD18,  RAD18p,  hRAD18,  C9J0Q4,  F8WAZ7 ...

Linkouts:  STRING  Pharos  UniProt  OMIM