MTUS1 disease associations
MTUS1 [ENSP00000262102]
Microtubule-associated tumor suppressor 1; Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth.
Synonyms: MTUS1, MTUS1p, hMTUS1, A0A0U1RQI2, H0YC63 ...