DISEASES

Disease-gene associations mined from literature

DAD1 disease associations

DAD1 [ENSP00000250498]

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation . N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). Required for the assembly of both SST3A- and SS3B-containing OST complexes. Loss of the DAD1 protein triggers apoptosis . ; Belongs to the DAD/OST2 family.

Synonyms:  DAD1,  DAD1p,  hDAD1,  A0A0B4J239,  F5GXX5 ...

Linkouts:  STRING  Pharos  UniProt  OMIM