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TAT | |||||
FAH | |||||
HPD | |||||
GSTZ1 | |||||
ALAD | |||||
HGD | |||||
AFP | |||||
SERPINA1 | |||||
OTC | |||||
PAH |
node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AFP | FAH | ENSP00000379138 | ENSP00000385080 | Alpha-fetoprotein; Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties; Belongs to the ALB/AFP/VDB family. | Fumarylacetoacetase; Fumarylacetoacetate hydrolase. | 0.776 |
AFP | SERPINA1 | ENSP00000379138 | ENSP00000416066 | Alpha-fetoprotein; Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties; Belongs to the ALB/AFP/VDB family. | Short peptide from AAT; Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin; Belongs to the serpin family. | 0.927 |
FAH | AFP | ENSP00000385080 | ENSP00000379138 | Fumarylacetoacetase; Fumarylacetoacetate hydrolase. | Alpha-fetoprotein; Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties; Belongs to the ALB/AFP/VDB family. | 0.776 |
FAH | GSTZ1 | ENSP00000385080 | ENSP00000451976 | Fumarylacetoacetase; Fumarylacetoacetate hydrolase. | Maleylacetoacetate isomerase; Bifunctional enzyme showing minimal glutathione-conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenz-2-oxa-1,3- diazole and maleylacetoacetate isomerase activity. Has also low glutathione peroxidase activity with T-butyl and cumene hydroperoxides. Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid. | 0.997 |
FAH | HGD | ENSP00000385080 | ENSP00000283871 | Fumarylacetoacetase; Fumarylacetoacetate hydrolase. | Homogentisate 1,2-dioxygenase. | 0.945 |
FAH | HPD | ENSP00000385080 | ENSP00000289004 | Fumarylacetoacetase; Fumarylacetoacetate hydrolase. | 4-hydroxyphenylpyruvate dioxygenase; Key enzyme in the degradation of tyrosine; Belongs to the 4HPPD family. | 0.993 |
FAH | TAT | ENSP00000385080 | ENSP00000348234 | Fumarylacetoacetase; Fumarylacetoacetate hydrolase. | Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine. | 0.935 |
GSTZ1 | FAH | ENSP00000451976 | ENSP00000385080 | Maleylacetoacetate isomerase; Bifunctional enzyme showing minimal glutathione-conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenz-2-oxa-1,3- diazole and maleylacetoacetate isomerase activity. Has also low glutathione peroxidase activity with T-butyl and cumene hydroperoxides. Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid. | Fumarylacetoacetase; Fumarylacetoacetate hydrolase. | 0.997 |
GSTZ1 | HGD | ENSP00000451976 | ENSP00000283871 | Maleylacetoacetate isomerase; Bifunctional enzyme showing minimal glutathione-conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenz-2-oxa-1,3- diazole and maleylacetoacetate isomerase activity. Has also low glutathione peroxidase activity with T-butyl and cumene hydroperoxides. Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid. | Homogentisate 1,2-dioxygenase. | 0.996 |
HGD | FAH | ENSP00000283871 | ENSP00000385080 | Homogentisate 1,2-dioxygenase. | Fumarylacetoacetase; Fumarylacetoacetate hydrolase. | 0.945 |
HGD | GSTZ1 | ENSP00000283871 | ENSP00000451976 | Homogentisate 1,2-dioxygenase. | Maleylacetoacetate isomerase; Bifunctional enzyme showing minimal glutathione-conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenz-2-oxa-1,3- diazole and maleylacetoacetate isomerase activity. Has also low glutathione peroxidase activity with T-butyl and cumene hydroperoxides. Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid. | 0.996 |
HGD | HPD | ENSP00000283871 | ENSP00000289004 | Homogentisate 1,2-dioxygenase. | 4-hydroxyphenylpyruvate dioxygenase; Key enzyme in the degradation of tyrosine; Belongs to the 4HPPD family. | 0.999 |
HGD | PAH | ENSP00000283871 | ENSP00000448059 | Homogentisate 1,2-dioxygenase. | Phenylalanine-4-hydroxylase; Catalyzes the hydroxylation of L-phenylalanine to L-tyrosine. Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. | 0.845 |
HGD | TAT | ENSP00000283871 | ENSP00000348234 | Homogentisate 1,2-dioxygenase. | Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine. | 0.807 |
HPD | FAH | ENSP00000289004 | ENSP00000385080 | 4-hydroxyphenylpyruvate dioxygenase; Key enzyme in the degradation of tyrosine; Belongs to the 4HPPD family. | Fumarylacetoacetase; Fumarylacetoacetate hydrolase. | 0.993 |
HPD | HGD | ENSP00000289004 | ENSP00000283871 | 4-hydroxyphenylpyruvate dioxygenase; Key enzyme in the degradation of tyrosine; Belongs to the 4HPPD family. | Homogentisate 1,2-dioxygenase. | 0.999 |
HPD | TAT | ENSP00000289004 | ENSP00000348234 | 4-hydroxyphenylpyruvate dioxygenase; Key enzyme in the degradation of tyrosine; Belongs to the 4HPPD family. | Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine. | 0.998 |
PAH | HGD | ENSP00000448059 | ENSP00000283871 | Phenylalanine-4-hydroxylase; Catalyzes the hydroxylation of L-phenylalanine to L-tyrosine. Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. | Homogentisate 1,2-dioxygenase. | 0.845 |
PAH | TAT | ENSP00000448059 | ENSP00000348234 | Phenylalanine-4-hydroxylase; Catalyzes the hydroxylation of L-phenylalanine to L-tyrosine. Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. | Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine. | 0.967 |
SERPINA1 | AFP | ENSP00000416066 | ENSP00000379138 | Short peptide from AAT; Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin; Belongs to the serpin family. | Alpha-fetoprotein; Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties; Belongs to the ALB/AFP/VDB family. | 0.927 |