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HGD | |||||
HPD | |||||
FAH | |||||
TAT | |||||
PAH | |||||
GSTZ1 | |||||
NIT2 | |||||
TYR | |||||
ADSL | |||||
MLYCD |
node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FAH | GSTZ1 | ENSP00000385080 | ENSP00000451976 | Fumarylacetoacetase; Fumarylacetoacetate hydrolase. | Maleylacetoacetate isomerase; Bifunctional enzyme showing minimal glutathione-conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenz-2-oxa-1,3- diazole and maleylacetoacetate isomerase activity. Has also low glutathione peroxidase activity with T-butyl and cumene hydroperoxides. Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid. | 0.997 |
FAH | HGD | ENSP00000385080 | ENSP00000283871 | Fumarylacetoacetase; Fumarylacetoacetate hydrolase. | Homogentisate 1,2-dioxygenase. | 0.945 |
FAH | HPD | ENSP00000385080 | ENSP00000289004 | Fumarylacetoacetase; Fumarylacetoacetate hydrolase. | 4-hydroxyphenylpyruvate dioxygenase; Key enzyme in the degradation of tyrosine; Belongs to the 4HPPD family. | 0.993 |
FAH | TAT | ENSP00000385080 | ENSP00000348234 | Fumarylacetoacetase; Fumarylacetoacetate hydrolase. | Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine. | 0.935 |
GSTZ1 | FAH | ENSP00000451976 | ENSP00000385080 | Maleylacetoacetate isomerase; Bifunctional enzyme showing minimal glutathione-conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenz-2-oxa-1,3- diazole and maleylacetoacetate isomerase activity. Has also low glutathione peroxidase activity with T-butyl and cumene hydroperoxides. Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid. | Fumarylacetoacetase; Fumarylacetoacetate hydrolase. | 0.997 |
GSTZ1 | HGD | ENSP00000451976 | ENSP00000283871 | Maleylacetoacetate isomerase; Bifunctional enzyme showing minimal glutathione-conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenz-2-oxa-1,3- diazole and maleylacetoacetate isomerase activity. Has also low glutathione peroxidase activity with T-butyl and cumene hydroperoxides. Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid. | Homogentisate 1,2-dioxygenase. | 0.996 |
HGD | FAH | ENSP00000283871 | ENSP00000385080 | Homogentisate 1,2-dioxygenase. | Fumarylacetoacetase; Fumarylacetoacetate hydrolase. | 0.945 |
HGD | GSTZ1 | ENSP00000283871 | ENSP00000451976 | Homogentisate 1,2-dioxygenase. | Maleylacetoacetate isomerase; Bifunctional enzyme showing minimal glutathione-conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenz-2-oxa-1,3- diazole and maleylacetoacetate isomerase activity. Has also low glutathione peroxidase activity with T-butyl and cumene hydroperoxides. Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid. | 0.996 |
HGD | HPD | ENSP00000283871 | ENSP00000289004 | Homogentisate 1,2-dioxygenase. | 4-hydroxyphenylpyruvate dioxygenase; Key enzyme in the degradation of tyrosine; Belongs to the 4HPPD family. | 0.999 |
HGD | PAH | ENSP00000283871 | ENSP00000448059 | Homogentisate 1,2-dioxygenase. | Phenylalanine-4-hydroxylase; Catalyzes the hydroxylation of L-phenylalanine to L-tyrosine. Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. | 0.845 |
HGD | TAT | ENSP00000283871 | ENSP00000348234 | Homogentisate 1,2-dioxygenase. | Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine. | 0.807 |
HPD | FAH | ENSP00000289004 | ENSP00000385080 | 4-hydroxyphenylpyruvate dioxygenase; Key enzyme in the degradation of tyrosine; Belongs to the 4HPPD family. | Fumarylacetoacetase; Fumarylacetoacetate hydrolase. | 0.993 |
HPD | HGD | ENSP00000289004 | ENSP00000283871 | 4-hydroxyphenylpyruvate dioxygenase; Key enzyme in the degradation of tyrosine; Belongs to the 4HPPD family. | Homogentisate 1,2-dioxygenase. | 0.999 |
HPD | TAT | ENSP00000289004 | ENSP00000348234 | 4-hydroxyphenylpyruvate dioxygenase; Key enzyme in the degradation of tyrosine; Belongs to the 4HPPD family. | Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine. | 0.998 |
PAH | HGD | ENSP00000448059 | ENSP00000283871 | Phenylalanine-4-hydroxylase; Catalyzes the hydroxylation of L-phenylalanine to L-tyrosine. Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. | Homogentisate 1,2-dioxygenase. | 0.845 |
PAH | TAT | ENSP00000448059 | ENSP00000348234 | Phenylalanine-4-hydroxylase; Catalyzes the hydroxylation of L-phenylalanine to L-tyrosine. Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. | Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine. | 0.967 |
PAH | TYR | ENSP00000448059 | ENSP00000263321 | Phenylalanine-4-hydroxylase; Catalyzes the hydroxylation of L-phenylalanine to L-tyrosine. Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. | Tyrosinase; This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone. Belongs to the tyrosinase family. | 0.938 |
TAT | FAH | ENSP00000348234 | ENSP00000385080 | Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine. | Fumarylacetoacetase; Fumarylacetoacetate hydrolase. | 0.935 |
TAT | HGD | ENSP00000348234 | ENSP00000283871 | Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine. | Homogentisate 1,2-dioxygenase. | 0.807 |
TAT | HPD | ENSP00000348234 | ENSP00000289004 | Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine. | 4-hydroxyphenylpyruvate dioxygenase; Key enzyme in the degradation of tyrosine; Belongs to the 4HPPD family. | 0.998 |