Your Input: | |||||
TIA1 | |||||
CD2 | |||||
NCAM1 | |||||
ASPG | |||||
TNFRSF8 | |||||
GZMB | |||||
PRF1 | |||||
CD7 | |||||
SPN | |||||
CD5 |
node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CD2 | CD5 | ENSP00000358490 | ENSP00000342681 | T-cell surface antigen CD2; CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function. | T-cell surface glycoprotein CD5; May act as a receptor in regulating T-cell proliferation. | 0.994 |
CD2 | CD7 | ENSP00000358490 | ENSP00000312027 | T-cell surface antigen CD2; CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function. | T-cell antigen CD7; Not yet known. | 0.979 |
CD2 | GZMB | ENSP00000358490 | ENSP00000216341 | T-cell surface antigen CD2; CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function. | Granzyme B; This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis; Belongs to the peptidase S1 family. Granzyme subfamily. | 0.874 |
CD2 | NCAM1 | ENSP00000358490 | ENSP00000480132 | T-cell surface antigen CD2; CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function. | Neural cell adhesion molecule 1; This protein is a cell adhesion molecule involved in neuron- neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. | 0.921 |
CD2 | PRF1 | ENSP00000358490 | ENSP00000398568 | T-cell surface antigen CD2; CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function. | Perforin-1; Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes. Belongs to the complement C6/C7/C8/C9 family. | 0.838 |
CD2 | SPN | ENSP00000358490 | ENSP00000498852 | T-cell surface antigen CD2; CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function. | CD43 cytoplasmic tail; Predominant cell surface sialoprotein of leukocytes which regulates multiple T-cell functions, including T-cell activation, proliferation, differentiation, trafficking and migration. Positively regulates T-cell trafficking to lymph-nodes via its association with ERM proteins (EZR, RDX and MSN) (By similarity). Negatively regulates Th2 cell differentiation and predisposes the differentiation of T-cells towards a Th1 lineage commitment. Promotes the expression of IFN-gamma by T-cells during T-cell receptor (TCR) activation of naive cells and induces the expression [...] | 0.817 |
CD2 | TIA1 | ENSP00000358490 | ENSP00000401371 | T-cell surface antigen CD2; CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function. | Nucleolysin TIA-1 isoform p40; Involved in alternative pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs). Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis. | 0.724 |
CD2 | TNFRSF8 | ENSP00000358490 | ENSP00000263932 | T-cell surface antigen CD2; CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function. | Tumor necrosis factor receptor superfamily member 8; Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa- B ; Belongs to the TNFR8 family. | 0.778 |
CD5 | CD2 | ENSP00000342681 | ENSP00000358490 | T-cell surface glycoprotein CD5; May act as a receptor in regulating T-cell proliferation. | T-cell surface antigen CD2; CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function. | 0.994 |
CD5 | CD7 | ENSP00000342681 | ENSP00000312027 | T-cell surface glycoprotein CD5; May act as a receptor in regulating T-cell proliferation. | T-cell antigen CD7; Not yet known. | 0.970 |
CD5 | NCAM1 | ENSP00000342681 | ENSP00000480132 | T-cell surface glycoprotein CD5; May act as a receptor in regulating T-cell proliferation. | Neural cell adhesion molecule 1; This protein is a cell adhesion molecule involved in neuron- neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. | 0.848 |
CD5 | SPN | ENSP00000342681 | ENSP00000498852 | T-cell surface glycoprotein CD5; May act as a receptor in regulating T-cell proliferation. | CD43 cytoplasmic tail; Predominant cell surface sialoprotein of leukocytes which regulates multiple T-cell functions, including T-cell activation, proliferation, differentiation, trafficking and migration. Positively regulates T-cell trafficking to lymph-nodes via its association with ERM proteins (EZR, RDX and MSN) (By similarity). Negatively regulates Th2 cell differentiation and predisposes the differentiation of T-cells towards a Th1 lineage commitment. Promotes the expression of IFN-gamma by T-cells during T-cell receptor (TCR) activation of naive cells and induces the expression [...] | 0.940 |
CD5 | TIA1 | ENSP00000342681 | ENSP00000401371 | T-cell surface glycoprotein CD5; May act as a receptor in regulating T-cell proliferation. | Nucleolysin TIA-1 isoform p40; Involved in alternative pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs). Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis. | 0.712 |
CD5 | TNFRSF8 | ENSP00000342681 | ENSP00000263932 | T-cell surface glycoprotein CD5; May act as a receptor in regulating T-cell proliferation. | Tumor necrosis factor receptor superfamily member 8; Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa- B ; Belongs to the TNFR8 family. | 0.844 |
CD7 | CD2 | ENSP00000312027 | ENSP00000358490 | T-cell antigen CD7; Not yet known. | T-cell surface antigen CD2; CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function. | 0.979 |
CD7 | CD5 | ENSP00000312027 | ENSP00000342681 | T-cell antigen CD7; Not yet known. | T-cell surface glycoprotein CD5; May act as a receptor in regulating T-cell proliferation. | 0.970 |
CD7 | NCAM1 | ENSP00000312027 | ENSP00000480132 | T-cell antigen CD7; Not yet known. | Neural cell adhesion molecule 1; This protein is a cell adhesion molecule involved in neuron- neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. | 0.898 |
CD7 | SPN | ENSP00000312027 | ENSP00000498852 | T-cell antigen CD7; Not yet known. | CD43 cytoplasmic tail; Predominant cell surface sialoprotein of leukocytes which regulates multiple T-cell functions, including T-cell activation, proliferation, differentiation, trafficking and migration. Positively regulates T-cell trafficking to lymph-nodes via its association with ERM proteins (EZR, RDX and MSN) (By similarity). Negatively regulates Th2 cell differentiation and predisposes the differentiation of T-cells towards a Th1 lineage commitment. Promotes the expression of IFN-gamma by T-cells during T-cell receptor (TCR) activation of naive cells and induces the expression [...] | 0.823 |
CD7 | TIA1 | ENSP00000312027 | ENSP00000401371 | T-cell antigen CD7; Not yet known. | Nucleolysin TIA-1 isoform p40; Involved in alternative pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs). Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis. | 0.712 |
CD7 | TNFRSF8 | ENSP00000312027 | ENSP00000263932 | T-cell antigen CD7; Not yet known. | Tumor necrosis factor receptor superfamily member 8; Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa- B ; Belongs to the TNFR8 family. | 0.794 |