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DISEASES
The following proteins in
Homo sapiens
appear to match your input.
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1) '9606.ENSP00000403888':
DISC1 - Disrupted in schizophrenia 1 protein; Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt- mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, includ [...]
[a.k.a. NP_001158023, FJ804205, NM_001164537.2]
2) '9606.DISC1FP1':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
3) '9606.ENSP00000297439':
DEFB1 - Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility.
[a.k.a. UPI0000001125, DEFB-1, 1672]
4) '9606.AC005932.1':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
5) '9606.ENSP00000316244':
HTR1A - 5-hydroxytryptamine receptor 1A; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second [...]
[a.k.a. R-HSA-388396, CAA40962.1, R-HSA-162582]
6) '9606.ENSP00000176183':
DRD4 - D(4) dopamine receptor; Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Activated by dopamine, but also by epinephrine and norepinephrine, and by numerous synthetic agonists and drugs. Agonist binding triggers signaling via G proteins that inhibit adenylyl cyclase. Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (By similarity).
[a.k.a. 5WIV, R-HSA-388396, DRD4-202]
7) '9606.ENSP00000261707':
SLC6A4 - Sodium-dependent serotonin transporter; Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.
[a.k.a. CCDS11256, NM_001045, ENST00000394821]
8) '9606.ENSP00000354859':
DRD2 - D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family.
[a.k.a. ENST00000355319, AF176812, R-HSA-162582]
9) '9606.ENSP00000483757':
DAOA - D-amino acid oxidase activator; Seems to activate D-amino acid oxidase.
[a.k.a. ENST00000473269, ENSP00000469539, NM_001161812]
10) '9606.ENSP00000414303':
BDNF - Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2. During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentia [...]
[a.k.a. R-HSA-9026519, KF459669, NM_001143811.1]
