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DISEASES
The following proteins in
Homo sapiens
appear to match your input.
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1) '9606.ENSP00000344666':
NF2 - Merlin; Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF [...]
[a.k.a. ENST00000403999, AAK54163.1, ENST00000403435]
2) '9606.ENSP00000389900':
DCUN1D4 - DCN1-like protein 4; Defective in cullin neddylation 1 domain containing 4.
[a.k.a. ENST00000381441, ENST00000510587.5, EAX05428.1]
3) '9606.ENSP00000350198':
SSTR2 - Somatostatin receptor type 2; Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 [...]
[a.k.a. R-HSA-388396, Q96GE0, CCDS11691]
4) '9606.ENSP00000496779':
LZTR1 - Leucine-zipper-like transcriptional regulator 1; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates ubiquitination of Ras (K-Ras/KRAS, N-Ras/NRAS and H-Ras/HRAS). Is a negative regulator of RAS-MAPK signaling that acts by controlling Ras levels and decreasing Ras association with membranes ; Belongs to the LZTR1 family.
[a.k.a. ENST00000415817, LZTR-1, UPI000D195DEE]
5) '9606.ENSP00000340883':
SMARCB1 - SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Core component of the BAF (hSWI/SNF) complex. This ATP- dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric struct [...]
[a.k.a. CCDS82699, NM_001317946.2, ENST00000644462.1]
6) '9606.ENSP00000351015':
NF1 - Neurofibromin truncated; Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity.
[a.k.a. J3KSB5, ENSP00000464678, ENST00000468273.1]
7) '9606.ENSP00000318944':
TRAF7 - E3 ubiquitin-protein ligase TRAF7; E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MAP3K3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators. Induces apoptosis when overexpressed. Plays a role in the phosphorylation of MAPK1 and/or MAPK3, probably via its interaction with MAP3K3.
[a.k.a. UPI000014186F, ENSP00000457735, ENST00000326181]
8) '9606.ENSP00000287641':
SST - Somatostatin-14; [Somatostatin-14]: Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH- stimulated secretion of GH1 and LH; the inhibition of ghrelin- stimulated secretion of GH1 can be further increased by neuronostatin.
[a.k.a. 1P2W, R-HSA-388396, R-HSA-162582]
9) '9606.5_8S_rRNA':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
10) '9606.ENSP00000450842':
TMEM30B - Cell cycle control protein 50B; Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate (Probable). Can mediate the export of alpha subunits ATP8A1, ATP8B1, ATP8B2 and ATP8B4 from the ER to th [...]
[a.k.a. Q3MIR4, NM_001017970.2, CCDS32093.1]
