10 items (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
		PHLDA1
		KRT15
		KRT20
		C17orf97
		CEACAM5
		PTGER4
		KRT7
		PIP
		KRT5
		DOCK8

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C17orf97	CEACAM5	ENSP00000353245	ENSP00000221992	Protein LIAT1; May be involved in ATE1-mediated N-terminal arginylation.	Carcinoembryonic antigen-related cell adhesion molecule 5; Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression. Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6. Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells. Belongs to the immunoglobulin superfamily. CEA family.	0.788
C17orf97	KRT5	ENSP00000353245	ENSP00000252242	Protein LIAT1; May be involved in ATE1-mediated N-terminal arginylation.	Keratin, type II cytoskeletal 5; Keratin 5; Belongs to the intermediate filament family.	0.824
C17orf97	KRT7	ENSP00000353245	ENSP00000329243	Protein LIAT1; May be involved in ATE1-mediated N-terminal arginylation.	Keratin, type II cytoskeletal 7; Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7). Belongs to the intermediate filament family.	0.960
C17orf97	PIP	ENSP00000353245	ENSP00000291009	Protein LIAT1; May be involved in ATE1-mediated N-terminal arginylation.	Prolactin induced protein; Belongs to the PIP family.	0.810
CEACAM5	C17orf97	ENSP00000221992	ENSP00000353245	Carcinoembryonic antigen-related cell adhesion molecule 5; Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression. Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6. Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells. Belongs to the immunoglobulin superfamily. CEA family.	Protein LIAT1; May be involved in ATE1-mediated N-terminal arginylation.	0.788
CEACAM5	KRT20	ENSP00000221992	ENSP00000167588	Carcinoembryonic antigen-related cell adhesion molecule 5; Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression. Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6. Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells. Belongs to the immunoglobulin superfamily. CEA family.	Keratin, type I cytoskeletal 20; Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity).	0.869
CEACAM5	KRT5	ENSP00000221992	ENSP00000252242	Carcinoembryonic antigen-related cell adhesion molecule 5; Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression. Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6. Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells. Belongs to the immunoglobulin superfamily. CEA family.	Keratin, type II cytoskeletal 5; Keratin 5; Belongs to the intermediate filament family.	0.753
CEACAM5	KRT7	ENSP00000221992	ENSP00000329243	Carcinoembryonic antigen-related cell adhesion molecule 5; Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression. Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6. Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells. Belongs to the immunoglobulin superfamily. CEA family.	Keratin, type II cytoskeletal 7; Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7). Belongs to the intermediate filament family.	0.883
KRT15	KRT5	ENSP00000377546	ENSP00000252242	Keratin, type I cytoskeletal 15; Keratin 15.	Keratin, type II cytoskeletal 5; Keratin 5; Belongs to the intermediate filament family.	0.749
KRT20	CEACAM5	ENSP00000167588	ENSP00000221992	Keratin, type I cytoskeletal 20; Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity).	Carcinoembryonic antigen-related cell adhesion molecule 5; Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression. Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6. Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells. Belongs to the immunoglobulin superfamily. CEA family.	0.869
KRT20	PIP	ENSP00000167588	ENSP00000291009	Keratin, type I cytoskeletal 20; Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity).	Prolactin induced protein; Belongs to the PIP family.	0.840
KRT5	C17orf97	ENSP00000252242	ENSP00000353245	Keratin, type II cytoskeletal 5; Keratin 5; Belongs to the intermediate filament family.	Protein LIAT1; May be involved in ATE1-mediated N-terminal arginylation.	0.824
KRT5	CEACAM5	ENSP00000252242	ENSP00000221992	Keratin, type II cytoskeletal 5; Keratin 5; Belongs to the intermediate filament family.	Carcinoembryonic antigen-related cell adhesion molecule 5; Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression. Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6. Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells. Belongs to the immunoglobulin superfamily. CEA family.	0.753
KRT5	KRT15	ENSP00000252242	ENSP00000377546	Keratin, type II cytoskeletal 5; Keratin 5; Belongs to the intermediate filament family.	Keratin, type I cytoskeletal 15; Keratin 15.	0.749
KRT7	C17orf97	ENSP00000329243	ENSP00000353245	Keratin, type II cytoskeletal 7; Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7). Belongs to the intermediate filament family.	Protein LIAT1; May be involved in ATE1-mediated N-terminal arginylation.	0.960
KRT7	CEACAM5	ENSP00000329243	ENSP00000221992	Keratin, type II cytoskeletal 7; Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7). Belongs to the intermediate filament family.	Carcinoembryonic antigen-related cell adhesion molecule 5; Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression. Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6. Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells. Belongs to the immunoglobulin superfamily. CEA family.	0.883
KRT7	PIP	ENSP00000329243	ENSP00000291009	Keratin, type II cytoskeletal 7; Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7). Belongs to the intermediate filament family.	Prolactin induced protein; Belongs to the PIP family.	0.848
PIP	C17orf97	ENSP00000291009	ENSP00000353245	Prolactin induced protein; Belongs to the PIP family.	Protein LIAT1; May be involved in ATE1-mediated N-terminal arginylation.	0.810
PIP	KRT20	ENSP00000291009	ENSP00000167588	Prolactin induced protein; Belongs to the PIP family.	Keratin, type I cytoskeletal 20; Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity).	0.840
PIP	KRT7	ENSP00000291009	ENSP00000329243	Prolactin induced protein; Belongs to the PIP family.	Keratin, type II cytoskeletal 7; Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7). Belongs to the intermediate filament family.	0.848