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DISEASES
The following proteins in
Homo sapiens
appear to match your input.
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1) '9606.ENSP00000306682':
PPM1D - Protein phosphatase 1D; Involved in the negative regulation of p53 expression. Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins. Mediates MAPK14 dephosphorylation and inactivation. Is also an important regulator of global heterochromatin silencing and critical in maintaining genome integrity (By similarity).
[a.k.a. 3.1.3.16, ENST00000590418.1, ENSG00000170836]
2) '9606.ENSP00000252137':
ESS2 - Splicing factor ESS-2 homolog; May be involved in pre-mRNA splicing.
[a.k.a. XR_002958714, Ess-2 splicing factor homolog, XM_006724330]
3) '9606.ENSP00000083182':
APPBP2 - Amyloid protein-binding protein 2; May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface.
[a.k.a. AAC83973.1, 10513, Hs.84084]
4) '9606.WT1-AS':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
5) '9606.ENSP00000320485':
ARID1A - AT-rich interactive domain-containing protein 1A; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors- specific chromatin remodeling complex (npBAF complex) and the neuron- specific chromatin remodeling complex (nBAF complex). During neural dev [...]
[a.k.a. AB001895, ARID1A-205, ENST00000324856]
6) '9606.ENSP00000292539':
PPP1R16A - Protein phosphatase 1 regulatory subunit 16A; Inhibits protein phosphatase 1 activity toward phosphorylase, myosin light chain and myosin substrates.
[a.k.a. NP_001316372.1, ENST00000529283.5, NP_001316374.1]
7) '9606.ENSP00000216133':
CBX7 - Chromobox protein homolog 7; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular [...]
[a.k.a. 23492, ENST00000475962, ENST00000490741.1]
8) '9606.hsa-miR-4723-3p':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
9) '9606.ENSP00000269305':
TP53 - Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]
[a.k.a. NM_001126113, ENSP00000481638, R-HSA-2559584]
10) '9606.ENSP00000289989':
C8orf58 - Uncharacterized protein C8orf58; Chromosome 8 open reading frame 58.
[a.k.a. UPI0005D0E8F6, NP_001013864.1, ENSP00000289989]
