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DISEASES
The following proteins in
Homo sapiens
appear to match your input.
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1) '9606.ENSP00000482313':
RECQL4 - ATP-dependent DNA helicase Q4; DNA-dependent ATPase. May modulate chromosome segregation. Belongs to the helicase family. RecQ subfamily.
[a.k.a. XM_011517384, XM_017013993.2, ENSG00000160957]
2) '9606.ENSP00000267163':
RB1 - Retinoblastoma-associated protein; Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransfer [...]
[a.k.a. R-HSA-2559584, R-HSA-69278, M27857]
3) '9606.ENSP00000269305':
TP53 - Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]
[a.k.a. NM_001126113, ENSP00000481638, R-HSA-2559584]
4) '9606.ENSP00000298139':
WRN - Werner syndrome ATP-dependent helicase; Multifunctional enzyme that has both magnesium and ATP- dependent DNA-helicase activity and 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double-stranded DNA. Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or durin [...]
[a.k.a. 2E1E, R-HSA-69620, uc003xio.5]
5) '9606.ENSP00000418915':
CDKN2A - Cyclin-dependent kinase inhibitor 2A; Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein; Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.
[a.k.a. 1DC2, NP_001350692, BAB91133.1]
6) '9606.ENSP00000347232':
BLM - Bloom syndrome protein; ATP-dependent DNA helicase that unwinds single- and double- stranded DNA in a 3'-5' direction. Participates in DNA replication and repair. Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA. Negatively regulates sister chromatid exchange (SCE). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution. Binds single- stranded DNA (ssDNA), forked duplex DNA and DNA Holliday junction.
[a.k.a. Q52M96, ENST00000559426, R-HSA-1474165]
7) '9606.ENSP00000257904':
CDK4 - Cyclin-dependent kinase 4; Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. [...]
[a.k.a. ENST00000312990, R-HSA-69278, R-HSA-1474165]
8) '9606.ENSP00000281043':
MYCN - N-myc proto-oncogene protein; Positively regulates the transcription of MYCNOS in neuroblastoma cells.
[a.k.a. NP_001280160.1, ENST00000321155, AAA36371.1]
9) '9606.ENSP00000351015':
NF1 - Neurofibromin truncated; Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity.
[a.k.a. J3KSB5, ENSP00000464678, ENST00000468273.1]
10) '9606.KCNQ5-IT1':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
