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DISEASES
The following proteins in
Homo sapiens
appear to match your input.
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1) '9606.ENSP00000375881':
ALPP - Alkaline phosphatase, placental.
[a.k.a. Regan isozyme, M12551, AAH94743.1]
2) '9606.ENSP00000379138':
AFP - Alpha-fetoprotein; Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties; Belongs to the ALB/AFP/VDB family.
[a.k.a. CHEMBL3712864, NP_001125.1, 174]
3) '9606.hsa-miR-371a-3p':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
4) '9606.ENSP00000288135':
KIT - Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...]
[a.k.a. P10721, 6GQM, 2E9W]
5) '9606.ENSP00000217086':
SALL4 - Sal-like protein 4; Transcription factor with a key role in the maintenance and self-renewal of embryonic and hematopoietic stem cells.
[a.k.a. R-HSA-9006925, Spalt like transcription factor 4, HPA015791]
6) '9606.ENSP00000259915':
POU5F1 - POU domain, class 5, transcription factor 1; Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. Belongs to the POU transcription factor family. Class-5 subfamily.
[a.k.a. OTF3, ENST00000448657, OCT4]
7) '9606.ENSP00000229307':
NANOG - Homeobox protein NANOG; Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT] [...]
[a.k.a. 79923, NM_001297698.2, 2KT0]
8) '9606.ENSP00000263932':
TNFRSF8 - Tumor necrosis factor receptor superfamily member 8; Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa- B ; Belongs to the TNFR8 family.
[a.k.a. URS00008B8180, NM_001281430, ENST00000417814.3]
9) '9606.ENSP00000314608':
KLHL11 - Kelch-like protein 11; Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.
[a.k.a. kelch like family member 11, R-HSA-8951664, ENST00000319121]
10) '9606.ENSP00000201031':
TFAP2C - Transcription factor AP-2 gamma; Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
[a.k.a. ENST00000371318, AP2-GAMMA, HGNC:11744]