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DISEASES
The following proteins in
Homo sapiens
appear to match your input.
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1) '9606.ENSP00000255977':
MKRN1 - E3 ubiquitin-protein ligase makorin-1; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II- dependent transcription.
[a.k.a. ENST00000255977.6, R-HSA-9006925, MKRN1-213]
2) '9606.ENSP00000289004':
HPD - 4-hydroxyphenylpyruvate dioxygenase; Key enzyme in the degradation of tyrosine; Belongs to the 4HPPD family.
[a.k.a. HPPDASE, GLOD3, PPD]
3) '9606.ENSP00000359489':
AFF2 - AF4/FMR2 family member 2; RNA-binding protein. Might be involved in alternative splicing regulation through an interaction with G-quartet RNA structure.
[a.k.a. ENST00000370458.5, AB101730, NP_001162596]
4) '9606.ENSP00000429633':
MYBL1 - Myb-related protein A; Transcription factor that specifically recognizes the sequence 5'-YAAC[GT]G-3'. Acts as a master regulator of male meiosis by promoting expression of piRNAs: activates expression of both piRNA precursor RNAs and expression of protein-coding genes involved in piRNA metabolism (By similarity). The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity (By simila [...]
[a.k.a. MYB proto-oncogene like 1, BC101188, ENSP00000428265]
5) '9606.ENSP00000498653':
DEK - Protein DEK; Involved in chromatin organization.
[a.k.a. CH471087, NM_001134709, ENST00000244776]
6) '9606.ENSP00000414095':
CUL2 - Cullin-2; Core component of multiple cullin-RING-based ECS (ElonginB/C- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the denedd [...]
[a.k.a. ENST00000279431, R-HSA-8951664, CUL2-208]
7) '9606.TRN-GTT2':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
8) '9606.ENSP00000370340':
NFIB - Nuclear factor 1 B-type; Transcriptional activator of GFAP, essential for proper brain development. Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. Belongs to the CTF/NF-I family.
[a.k.a. A0A1B0GVN4, AL137017, NP_001356391]
9) '9606.ENSP00000228918':
LTBR - Tumor necrosis factor receptor superfamily member 3; Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs.
[a.k.a. NM_002342.3, R-HSA-5676594, URS0000EA656A]
10) '9606.ENSP00000252242':
KRT5 - Keratin, type II cytoskeletal 5; Keratin 5; Belongs to the intermediate filament family.
[a.k.a. 3852, ENSP00000449651, CCDS8830]
