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DISEASES
The following proteins in
Homo sapiens
appear to match your input.
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1) '9606.ENSP00000310998':
NAGPA - N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase; Catalyzes the second step in the formation of the mannose 6- phosphate targeting signal on lysosomal enzyme oligosaccharides by removing GlcNAc residues from GlcNAc-alpha-P-mannose moieties, which are formed in the first step. Also hydrolyzes UDP-GlcNAc, a sugar donor for Golgi N-acetylglucosaminyltransferases.
[a.k.a. UPI00028411FA, HPA064055, AC026458]
2) '9606.ENSP00000381034':
SOCS6 - Suppressor of cytokine signaling 6; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5- SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor.
[a.k.a. Cish4, UPI0000072C28, R-HSA-8951664]
3) '9606.ENSP00000204679':
GNPTG - N-acetylglucosamine-1-phosphotransferase subunit gamma; Non-catalytic subunit of the N-acetylglucosamine-1- phosphotransferase complex, an enzyme that catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. Binds and presents the high mannose glycans of the acceptor to the catalytic alpha and beta subunits (GNPTAB). Enhances the rate of N-acetylglucosamine-1-phosphate transfer to the oligosaccharides of acid hydrolase acceptors.
[a.k.a. ENST00000529957, ENST00000534197, Q9UJJ9]
4) '9606.ENSP00000261842':
AP4E1 - AP-4 complex subunit epsilon-1; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper [...]
[a.k.a. XM_005254264, ENST00000560508.1, UPI00022F8515]
5) '9606.ENSP00000299314':
GNPTAB - N-acetylglucosamine-1-phosphotransferase subunits alpha/beta; Catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. M6P residues are required to bind to the M6P receptors (MPR), which mediate the vesicular transport of lysosomal enzymes to the endosomal/prelysosomal compartment.
[a.k.a. ENST00000647144, ENSP00000308378, ENST00000299314.11]
6) '9606.ENSP00000386200':
FOXP2 - Forkhead box protein P2; Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels. Involved in neural mechanisms mediating the development of speech and language.
[a.k.a. ENSP00000377133, ABG77460.1, HPA001679]
7) '9606.ENSP00000385892':
PLEKHB2 - Pleckstrin homology domain-containing family B member 2; Involved in retrograde transport of recycling endosomes.
[a.k.a. NP_001253997, NP_001253995.1, ENST00000234115]
8) '9606.LINC01554':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
9) '9606.ENSP00000330341':
SOCS3 - Suppressor of cytokine signaling 3; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL [...]
[a.k.a. EAW89521.1, R-HSA-8951664, NM_003955.4]
10) '9606.ENSP00000216200':
PVALB - Parvalbumin alpha; In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions; Belongs to the parvalbumin family.
[a.k.a. 5816, ENST00000216200, Z82184]
