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DISEASES
The following proteins in
Homo sapiens
appear to match your input.
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1) '9606.ENSP00000297261':
SHH - Sonic hedgehog protein N-product; [Sonic hedgehog protein]: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity).
[a.k.a. ENST00000435425, 6N7H, UPI0000135942]
2) '9606.ENSP00000332353':
PTCH1 - Protein patched homolog 1; Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis. Belongs to the patched family.
[a.k.a. 6N7H, ENST00000551845, PTCH1-225]
3) '9606.ENSP00000358918':
SUFU - Suppressor of fused homolog; Negative regulator in the hedgehog/smoothened signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Down-regulates GLI2-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling (By similarity). Regulates the formation of eit [...]
[a.k.a. 1M1L, R-HSA-162582, ENST00000423559]
4) '9606.ENSP00000249373':
SMO - Smoothened homolog; G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7, GLI2 and GLI3 in the cilia. Interacts with DLG5 at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity).
[a.k.a. CRJS, Protein Gx, 4O9R]
5) '9606.ENSP00000281043':
MYCN - N-myc proto-oncogene protein; Positively regulates the transcription of MYCNOS in neuroblastoma cells.
[a.k.a. NP_001280160.1, ENST00000321155, AAA36371.1]
6) '9606.ENSP00000390436':
GLI2 - Zinc finger protein GLI2; Functions as transcription regulator in the hedgehog (Hh) pathway. Functions as transcriptional activator. May also function as transcriptional repressor (By similarity). Requires STK36 for full transcriptional activator activity. Required for normal embryonic development. [Isoform 5]: Acts as a transcriptional repressor.
[a.k.a. ENSP00000403715, 2736, GLI2-205]
7) '9606.ENSP00000373340':
BRPF1 - Peregrin; Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Preferentially mediates histone H3-K23 acetylation. Positively regulates the transcription of RUNX1 and RUNX2.
[a.k.a. ENSP00000402485, 3L42, CCDS82730.1]
8) '9606.ENSP00000436713':
KBTBD4 - Kelch repeat and BTB domain containing 4.
[a.k.a. NM_018095, Kelch repeat and BTB domain-containing protein 4, NP_057590]
9) '9606.ENSP00000494040':
DDX3X - ATP-dependent RNA helicase DDX3X; Multifunctional ATP-dependent RNA helicase. The ATPase activity can be stimulated by various ribo-and deoxynucleic acids indicative for a relaxed substrate specificity. In vitro can unwind partially double- stranded DNA with a preference for 5'-single-stranded DNA overhangs. Binds RNA G-quadruplex (rG4s) structures, including those located in the 5'-UTR of NRAS mRNA. Involved in many cellular processes, which do not necessarily require its ATPase/helicase catalytic activities (Probable). Involved in transcription regulation. Positively regulates CDKN1A [...]
[a.k.a. UPI000D18B917, A0A0D9SG12, ENST00000647219]
10) '9606.hsa-miR-656-3p':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
