Your Input: | |||||
AVP | |||||
AVPR2 | |||||
AQP2 | |||||
POMC | |||||
NPPA | |||||
REN | |||||
LGI1 | |||||
OXT | |||||
PRL | |||||
ALB |
node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALB | POMC | ENSP00000295897 | ENSP00000384092 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs (Probable). Its main function is the regulation of the colloidal osmotic pressure of blood (Probable). Major zinc transporter in plasma, typically binds about 80% of all plasma zinc. Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific man [...] | Corticotropin-like intermediary peptide; [Corticotropin]: Stimulates the adrenal glands to release cortisol. [Melanocyte-stimulating hormone beta]: Increases the pigmentation of skin by increasing melanin production in melanocytes. [Met-enkephalin]: Endogenous opiate; Belongs to the POMC family. | 0.822 |
ALB | REN | ENSP00000295897 | ENSP00000272190 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs (Probable). Its main function is the regulation of the colloidal osmotic pressure of blood (Probable). Major zinc transporter in plasma, typically binds about 80% of all plasma zinc. Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific man [...] | Renin; Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. | 0.830 |
AQP2 | AVP | ENSP00000199280 | ENSP00000369647 | Aquaporin-2; Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Plays an essential role in renal water homeostasis. | Vasopressin-neurophysin 2-copeptin; Neurophysin 2 specifically binds vasopressin. | 0.915 |
AQP2 | AVPR2 | ENSP00000199280 | ENSP00000496396 | Aquaporin-2; Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Plays an essential role in renal water homeostasis. | Vasopressin V2 receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. | 0.982 |
AVP | AQP2 | ENSP00000369647 | ENSP00000199280 | Vasopressin-neurophysin 2-copeptin; Neurophysin 2 specifically binds vasopressin. | Aquaporin-2; Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Plays an essential role in renal water homeostasis. | 0.915 |
AVP | AVPR2 | ENSP00000369647 | ENSP00000496396 | Vasopressin-neurophysin 2-copeptin; Neurophysin 2 specifically binds vasopressin. | Vasopressin V2 receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. | 0.999 |
AVP | NPPA | ENSP00000369647 | ENSP00000365663 | Vasopressin-neurophysin 2-copeptin; Neurophysin 2 specifically binds vasopressin. | Atrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. | 0.787 |
AVP | OXT | ENSP00000369647 | ENSP00000217386 | Vasopressin-neurophysin 2-copeptin; Neurophysin 2 specifically binds vasopressin. | Oxytocin-neurophysin 1; Neurophysin 1 specifically binds oxytocin. | 0.959 |
AVP | POMC | ENSP00000369647 | ENSP00000384092 | Vasopressin-neurophysin 2-copeptin; Neurophysin 2 specifically binds vasopressin. | Corticotropin-like intermediary peptide; [Corticotropin]: Stimulates the adrenal glands to release cortisol. [Melanocyte-stimulating hormone beta]: Increases the pigmentation of skin by increasing melanin production in melanocytes. [Met-enkephalin]: Endogenous opiate; Belongs to the POMC family. | 0.879 |
AVP | REN | ENSP00000369647 | ENSP00000272190 | Vasopressin-neurophysin 2-copeptin; Neurophysin 2 specifically binds vasopressin. | Renin; Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. | 0.825 |
AVPR2 | AQP2 | ENSP00000496396 | ENSP00000199280 | Vasopressin V2 receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. | Aquaporin-2; Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Plays an essential role in renal water homeostasis. | 0.982 |
AVPR2 | AVP | ENSP00000496396 | ENSP00000369647 | Vasopressin V2 receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. | Vasopressin-neurophysin 2-copeptin; Neurophysin 2 specifically binds vasopressin. | 0.999 |
AVPR2 | OXT | ENSP00000496396 | ENSP00000217386 | Vasopressin V2 receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. | Oxytocin-neurophysin 1; Neurophysin 1 specifically binds oxytocin. | 0.777 |
AVPR2 | REN | ENSP00000496396 | ENSP00000272190 | Vasopressin V2 receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. | Renin; Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. | 0.713 |
NPPA | AVP | ENSP00000365663 | ENSP00000369647 | Atrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. | Vasopressin-neurophysin 2-copeptin; Neurophysin 2 specifically binds vasopressin. | 0.787 |
NPPA | REN | ENSP00000365663 | ENSP00000272190 | Atrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. | Renin; Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. | 0.941 |
OXT | AVP | ENSP00000217386 | ENSP00000369647 | Oxytocin-neurophysin 1; Neurophysin 1 specifically binds oxytocin. | Vasopressin-neurophysin 2-copeptin; Neurophysin 2 specifically binds vasopressin. | 0.959 |
OXT | AVPR2 | ENSP00000217386 | ENSP00000496396 | Oxytocin-neurophysin 1; Neurophysin 1 specifically binds oxytocin. | Vasopressin V2 receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. | 0.777 |
OXT | POMC | ENSP00000217386 | ENSP00000384092 | Oxytocin-neurophysin 1; Neurophysin 1 specifically binds oxytocin. | Corticotropin-like intermediary peptide; [Corticotropin]: Stimulates the adrenal glands to release cortisol. [Melanocyte-stimulating hormone beta]: Increases the pigmentation of skin by increasing melanin production in melanocytes. [Met-enkephalin]: Endogenous opiate; Belongs to the POMC family. | 0.936 |
OXT | PRL | ENSP00000217386 | ENSP00000302150 | Oxytocin-neurophysin 1; Neurophysin 1 specifically binds oxytocin. | Prolactin; Prolactin acts primarily on the mammary gland by promoting lactation; Belongs to the somatotropin/prolactin family. | 0.899 |