Your Input: | |||||
MBOAT7 | |||||
CTSD | |||||
APOC3 | |||||
GNPTG | |||||
NAGLU | |||||
ARSA | |||||
GLA | |||||
PNPLA3 | |||||
GRN | |||||
IDUA |
node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARSA | GLA | ENSP00000216124 | ENSP00000218516 | Arylsulfatase A component B; Hydrolyzes cerebroside sulfate. | Galactosidase alpha; Belongs to the glycosyl hydrolase 27 family. | 0.974 |
ARSA | IDUA | ENSP00000216124 | ENSP00000247933 | Arylsulfatase A component B; Hydrolyzes cerebroside sulfate. | alpha-L-iduronidase. | 0.734 |
CTSD | GRN | ENSP00000236671 | ENSP00000053867 | Cathepsin D heavy chain; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. | Paragranulin; Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation. Regulates protein trafficking to lysosomes and, also the activity of lysosomal enzymes. Facilitates also the acidification of lysosomes, causing degradation of mature CTSD by CTSB. In addition, functions as wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures (By similarity). Also promotes epithelia [...] | 0.866 |
GLA | ARSA | ENSP00000218516 | ENSP00000216124 | Galactosidase alpha; Belongs to the glycosyl hydrolase 27 family. | Arylsulfatase A component B; Hydrolyzes cerebroside sulfate. | 0.974 |
GRN | CTSD | ENSP00000053867 | ENSP00000236671 | Paragranulin; Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation. Regulates protein trafficking to lysosomes and, also the activity of lysosomal enzymes. Facilitates also the acidification of lysosomes, causing degradation of mature CTSD by CTSB. In addition, functions as wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures (By similarity). Also promotes epithelia [...] | Cathepsin D heavy chain; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. | 0.866 |
IDUA | ARSA | ENSP00000247933 | ENSP00000216124 | alpha-L-iduronidase. | Arylsulfatase A component B; Hydrolyzes cerebroside sulfate. | 0.734 |
IDUA | NAGLU | ENSP00000247933 | ENSP00000225927 | alpha-L-iduronidase. | Alpha-N-acetylglucosaminidase 77 kDa form; Involved in the degradation of heparan sulfate. | 0.810 |
MBOAT7 | PNPLA3 | ENSP00000245615 | ENSP00000216180 | Lysophospholipid acyltransferase 7; Acyltransferase which contributes to the regulation of free arachidonic acid (AA) in the cell through the remodeling of phospholipids. Mediates the conversion of lysophosphatidylinositol (1- acylglycerophosphatidylinositol or LPI) into phosphatidylinositol (1,2- diacyl-sn-glycero-3-phosphoinositol or PI) (LPIAT activity). Prefers arachidonoyl-CoA as the acyl donor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle. Required for cortical lamination during brain [...] | 1-acylglycerol-3-phosphate O-acyltransferase PNPLA3; Specifically catalyzes coenzyme A (CoA)-dependent acylation of 1-acyl-sn-glycerol 3-phosphate (2-lysophosphatidic acid/LPA) to generate phosphatidic acid (PA), an important metabolic intermediate and precursor for both triglycerides and glycerophospholipids. Does not esterify other lysophospholipids. Acyl donors are long chain (at least C16) fatty acyl-CoAs: arachidonoyl-CoA, linoleoyl-CoA, oleoyl-CoA and at a lesser extent palmitoyl-CoA. Additionally possesses low triacylglycerol lipase and CoA-independent acylglycerol transacylase [...] | 0.886 |
NAGLU | IDUA | ENSP00000225927 | ENSP00000247933 | Alpha-N-acetylglucosaminidase 77 kDa form; Involved in the degradation of heparan sulfate. | alpha-L-iduronidase. | 0.810 |
PNPLA3 | MBOAT7 | ENSP00000216180 | ENSP00000245615 | 1-acylglycerol-3-phosphate O-acyltransferase PNPLA3; Specifically catalyzes coenzyme A (CoA)-dependent acylation of 1-acyl-sn-glycerol 3-phosphate (2-lysophosphatidic acid/LPA) to generate phosphatidic acid (PA), an important metabolic intermediate and precursor for both triglycerides and glycerophospholipids. Does not esterify other lysophospholipids. Acyl donors are long chain (at least C16) fatty acyl-CoAs: arachidonoyl-CoA, linoleoyl-CoA, oleoyl-CoA and at a lesser extent palmitoyl-CoA. Additionally possesses low triacylglycerol lipase and CoA-independent acylglycerol transacylase [...] | Lysophospholipid acyltransferase 7; Acyltransferase which contributes to the regulation of free arachidonic acid (AA) in the cell through the remodeling of phospholipids. Mediates the conversion of lysophosphatidylinositol (1- acylglycerophosphatidylinositol or LPI) into phosphatidylinositol (1,2- diacyl-sn-glycero-3-phosphoinositol or PI) (LPIAT activity). Prefers arachidonoyl-CoA as the acyl donor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle. Required for cortical lamination during brain [...] | 0.886 |