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DISEASES
The following proteins in
Homo sapiens
appear to match your input.
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1) '9606.ENSP00000418915':
CDKN2A - Cyclin-dependent kinase inhibitor 2A; Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein; Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.
[a.k.a. 1DC2, NP_001350692, BAB91133.1]
2) '9606.ENSP00000358045':
ECM1 - Extracellular matrix protein 1; Involved in endochondral bone formation as negative regulator of bone mineralization. Stimulates the proliferation of endothelial cells and promotes angiogenesis. Inhibits MMP9 proteolytic activity.
[a.k.a. Q5T5G5, AK292435, ENSP00000358043]
3) '9606.MGC32805':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
4) '9606.ENSP00000217289':
FERMT1 - Fermitin family homolog 1; Involved in cell adhesion. Contributes to integrin activation. When coexpressed with talin, potentiates activation of ITGA2B. Required for normal keratinocyte proliferation. Required for normal polarization of basal keratinocytes in skin, and for normal cell shape. Required for normal adhesion of keratinocytes to fibronectin and laminin, and for normal keratinocyte migration to wound sites. May mediate TGF-beta 1 signaling in tumor progression. Belongs to the kindlin family.
[a.k.a. AF443278, FERMT1-204, NP_060141.3]
5) '9606.ENSP00000477587':
SRD5A2 - 3-oxo-5-alpha-steroid 4-dehydrogenase 2; Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5- alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
[a.k.a. R-HSA-556833, M74047, XP_011531374.1]
6) '9606.ENSP00000269305':
TP53 - Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]
[a.k.a. NM_001126113, ENSP00000481638, R-HSA-2559584]
7) '9606.ENSP00000261369':
SNX24 - Sorting nexin-24; May be involved in several stages of intracellular trafficking; Belongs to the sorting nexin family.
[a.k.a. Q9Y343, XM_017009394, ENST00000395451]
8) '9606.ENSP00000011653':
CD4 - T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]
[a.k.a. R-HSA-162587, 3JCC, 4Q6I]
9) '9606.ENSP00000255030':
CRP - C-reactive protein(1-205); Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.
[a.k.a. R-HSA-173623, CCDS30911, CRP-207]
10) '9606.ENSP00000442954':
APC2 - Adenomatous polyposis coli protein 2; Stabilizes microtubules and may regulate actin fiber dynamics through the activation of Rho family GTPases. May also function in Wnt signaling by promoting the rapid degradation of CTNNB1. Belongs to the adenomatous polyposis coli (APC) family.
[a.k.a. O95996, K7EN62, ENST00000590469.5]
