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DISEASES
The following proteins in
Homo sapiens
appear to match your input.
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1) '9606.ENSP00000288135':
KIT - Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...]
[a.k.a. P10721, 6GQM, 2E9W]
2) '9606.ENSP00000358548':
NRAS - GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
[a.k.a. R-HSA-9026519, R-HSA-388396, R-HSA-1643713]
3) '9606.ENSP00000419060':
BRAF - Serine/threonine-protein kinase B-raf; Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway. May play a role in the postsynaptic responses of hippocampal neurons ; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.
[a.k.a. CAQ43114.1, ENST00000644650, B6HY62]
4) '9606.ENSP00000299084':
SPRED1 - Sprouty-related, EVH1 domain-containing protein 1; Tyrosine kinase substrate that inhibits growth-factor- mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow (By similarity).
[a.k.a. XM_011521289.3, R-HSA-190236, R-HSA-162582]
5) '9606.ENSP00000351015':
NF1 - Neurofibromin truncated; Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity.
[a.k.a. J3KSB5, ENSP00000464678, ENST00000468273.1]
6) '9606.ENSP00000335321':
SF3B1 - Splicing factor 3B subunit 1; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). May also be involved [...]
[a.k.a. 2PEH, AF070540, Prp10]
7) '9606.ENSP00000078429':
GNA11 - Guanine nucleotide-binding protein subunit alpha-11; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C.
[a.k.a. R-HSA-388396, ENSG00000088256, GNA11-203]
8) '9606.ENSP00000497102':
CTLA4 - Cytotoxic T-lymphocyte protein 4; Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
[a.k.a. 1493, uc002vak.3, NM_005214]
9) '9606.ENSP00000370989':
CD274 - Programmed cell death 1 ligand 1; Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response. Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10).
[a.k.a. 5JDR, NM_001267706, 3SBW]
10) '9606.hsa-miR-4712-5p':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
