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DISEASES
The following proteins in
Homo sapiens
appear to match your input.
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1) '9606.ENSP00000314151':
KLK3 - Prostate-specific antigen; Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.
[a.k.a. BAG35776.1, HPA000764, AAH50595.2]
2) '9606.ENSP00000347046':
PDE5A - cGMP-specific 3',5'-cyclic phosphodiesterase; Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. Specifically regulates nitric-oxide- generated cGMP.
[a.k.a. uc003idf.4, NP_246273.2, PDE5A-204]
3) '9606.ENSP00000221930':
TGFB1 - Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...]
[a.k.a. R-HSA-2129379, R-HSA-170834, ENST00000221930.5]
4) '9606.ENSP00000314792':
BOLL - Protein boule-like; Probable RNA-binding protein, which may be required during spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation (By similarity); Belongs to the RRM DAZ family.
[a.k.a. CCDS63081.1, 66037, NP_149019.1]
5) '9606.ENSP00000217289':
FERMT1 - Fermitin family homolog 1; Involved in cell adhesion. Contributes to integrin activation. When coexpressed with talin, potentiates activation of ITGA2B. Required for normal keratinocyte proliferation. Required for normal polarization of basal keratinocytes in skin, and for normal cell shape. Required for normal adhesion of keratinocytes to fibronectin and laminin, and for normal keratinocyte migration to wound sites. May mediate TGF-beta 1 signaling in tumor progression. Belongs to the kindlin family.
[a.k.a. AF443278, FERMT1-204, NP_060141.3]
6) '9606.ENSP00000256999':
FOLH1 - Glutamate carboxypeptidase 2; Has both folate hydrolase and N-acetylated-alpha-linked- acidic dipeptidase (NAALADase) activity. Has a preference for tri- alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Involved in prostate tumor progression.
[a.k.a. 2JBK, 4OC1, PSM]
7) '9606.ENSP00000216211':
UPK3A - Uroplakin-3a; Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity).
[a.k.a. ENSP00000216211, UPK3, Q32N05]
8) '9606.ENSP00000303507':
BCR - Breakpoint cluster region protein; Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form. The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound t [...]
[a.k.a. ENST00000292697, AB209991, D22S11]
9) '9606.hsa-miR-6720-3p':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
10) '9606.ENSP00000323856':
PLEC - Plectin; Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity.
[a.k.a. PCN, NP_958782.1, EBSO]
