Your Input: | |||||
STS | |||||
PUDP | |||||
VCX3A | |||||
PNPLA4 | |||||
VCX2 | |||||
TGM1 | |||||
FLG | |||||
ABCA12 | |||||
VCX | |||||
NIPAL4 |
node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABCA12 | NIPAL4 | ENSP00000272895 | ENSP00000311687 | ATP-binding cassette sub-family A member 12; Probable transporter involved in lipid homeostasis; Belongs to the ABC transporter superfamily. ABCA family. | Magnesium transporter NIPA4; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Ba(2+), Mn(2+), Sr(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity). May be a receptor for ligands (trioxilins A3 and B3) from the hepoxilin pathway. | 0.924 |
ABCA12 | TGM1 | ENSP00000272895 | ENSP00000206765 | ATP-binding cassette sub-family A member 12; Probable transporter involved in lipid homeostasis; Belongs to the ABC transporter superfamily. ABCA family. | Protein-glutamine gamma-glutamyltransferase K; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation ; Belongs to the transglutaminase superfamily. Transglutaminase family. | 0.952 |
FLG | TGM1 | ENSP00000357789 | ENSP00000206765 | Filaggrin; Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis. | Protein-glutamine gamma-glutamyltransferase K; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation ; Belongs to the transglutaminase superfamily. Transglutaminase family. | 0.907 |
NIPAL4 | ABCA12 | ENSP00000311687 | ENSP00000272895 | Magnesium transporter NIPA4; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Ba(2+), Mn(2+), Sr(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity). May be a receptor for ligands (trioxilins A3 and B3) from the hepoxilin pathway. | ATP-binding cassette sub-family A member 12; Probable transporter involved in lipid homeostasis; Belongs to the ABC transporter superfamily. ABCA family. | 0.924 |
NIPAL4 | TGM1 | ENSP00000311687 | ENSP00000206765 | Magnesium transporter NIPA4; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Ba(2+), Mn(2+), Sr(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity). May be a receptor for ligands (trioxilins A3 and B3) from the hepoxilin pathway. | Protein-glutamine gamma-glutamyltransferase K; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation ; Belongs to the transglutaminase superfamily. Transglutaminase family. | 0.959 |
PNPLA4 | PUDP | ENSP00000370430 | ENSP00000396452 | Patatin-like phospholipase domain-containing protein 4; Lipid hydrolase. | Pseudouridine-5'-phosphatase; Dephosphorylates pseudouridine 5'-phosphate, a potential intermediate in rRNA degradation. Pseudouridine is then excreted intact in urine; Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. | 0.872 |
PNPLA4 | VCX3A | ENSP00000370430 | ENSP00000370479 | Patatin-like phospholipase domain-containing protein 4; Lipid hydrolase. | Variable charge X-linked protein 3; May mediate a process in spermatogenesis or may play a role in sex ratio distortion; Belongs to the VCX/VCY family. | 0.700 |
PUDP | PNPLA4 | ENSP00000396452 | ENSP00000370430 | Pseudouridine-5'-phosphatase; Dephosphorylates pseudouridine 5'-phosphate, a potential intermediate in rRNA degradation. Pseudouridine is then excreted intact in urine; Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. | Patatin-like phospholipase domain-containing protein 4; Lipid hydrolase. | 0.872 |
PUDP | STS | ENSP00000396452 | ENSP00000217961 | Pseudouridine-5'-phosphatase; Dephosphorylates pseudouridine 5'-phosphate, a potential intermediate in rRNA degradation. Pseudouridine is then excreted intact in urine; Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. | Steryl-sulfatase; Catalyzes the conversion of sulfated steroid precursors, such as dehydroepiandrosterone sulfate (DHEA-S) and estrone sulfate to the free steroid. | 0.872 |
PUDP | VCX3A | ENSP00000396452 | ENSP00000370479 | Pseudouridine-5'-phosphatase; Dephosphorylates pseudouridine 5'-phosphate, a potential intermediate in rRNA degradation. Pseudouridine is then excreted intact in urine; Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. | Variable charge X-linked protein 3; May mediate a process in spermatogenesis or may play a role in sex ratio distortion; Belongs to the VCX/VCY family. | 0.720 |
STS | PUDP | ENSP00000217961 | ENSP00000396452 | Steryl-sulfatase; Catalyzes the conversion of sulfated steroid precursors, such as dehydroepiandrosterone sulfate (DHEA-S) and estrone sulfate to the free steroid. | Pseudouridine-5'-phosphatase; Dephosphorylates pseudouridine 5'-phosphate, a potential intermediate in rRNA degradation. Pseudouridine is then excreted intact in urine; Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. | 0.872 |
STS | VCX | ENSP00000217961 | ENSP00000370447 | Steryl-sulfatase; Catalyzes the conversion of sulfated steroid precursors, such as dehydroepiandrosterone sulfate (DHEA-S) and estrone sulfate to the free steroid. | Variable charge X-linked protein 1; May mediate a process in spermatogenesis or may play a role in sex ratio distortion; Belongs to the VCX/VCY family. | 0.776 |
STS | VCX2 | ENSP00000217961 | ENSP00000321309 | Steryl-sulfatase; Catalyzes the conversion of sulfated steroid precursors, such as dehydroepiandrosterone sulfate (DHEA-S) and estrone sulfate to the free steroid. | Variable charge X-linked protein 2; May mediate a process in spermatogenesis or may play a role in sex ratio distortion; Belongs to the VCX/VCY family. | 0.776 |
STS | VCX3A | ENSP00000217961 | ENSP00000370479 | Steryl-sulfatase; Catalyzes the conversion of sulfated steroid precursors, such as dehydroepiandrosterone sulfate (DHEA-S) and estrone sulfate to the free steroid. | Variable charge X-linked protein 3; May mediate a process in spermatogenesis or may play a role in sex ratio distortion; Belongs to the VCX/VCY family. | 0.776 |
TGM1 | ABCA12 | ENSP00000206765 | ENSP00000272895 | Protein-glutamine gamma-glutamyltransferase K; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation ; Belongs to the transglutaminase superfamily. Transglutaminase family. | ATP-binding cassette sub-family A member 12; Probable transporter involved in lipid homeostasis; Belongs to the ABC transporter superfamily. ABCA family. | 0.952 |
TGM1 | FLG | ENSP00000206765 | ENSP00000357789 | Protein-glutamine gamma-glutamyltransferase K; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation ; Belongs to the transglutaminase superfamily. Transglutaminase family. | Filaggrin; Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis. | 0.907 |
TGM1 | NIPAL4 | ENSP00000206765 | ENSP00000311687 | Protein-glutamine gamma-glutamyltransferase K; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation ; Belongs to the transglutaminase superfamily. Transglutaminase family. | Magnesium transporter NIPA4; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Ba(2+), Mn(2+), Sr(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity). May be a receptor for ligands (trioxilins A3 and B3) from the hepoxilin pathway. | 0.959 |
VCX | STS | ENSP00000370447 | ENSP00000217961 | Variable charge X-linked protein 1; May mediate a process in spermatogenesis or may play a role in sex ratio distortion; Belongs to the VCX/VCY family. | Steryl-sulfatase; Catalyzes the conversion of sulfated steroid precursors, such as dehydroepiandrosterone sulfate (DHEA-S) and estrone sulfate to the free steroid. | 0.776 |
VCX2 | STS | ENSP00000321309 | ENSP00000217961 | Variable charge X-linked protein 2; May mediate a process in spermatogenesis or may play a role in sex ratio distortion; Belongs to the VCX/VCY family. | Steryl-sulfatase; Catalyzes the conversion of sulfated steroid precursors, such as dehydroepiandrosterone sulfate (DHEA-S) and estrone sulfate to the free steroid. | 0.776 |
VCX3A | PNPLA4 | ENSP00000370479 | ENSP00000370430 | Variable charge X-linked protein 3; May mediate a process in spermatogenesis or may play a role in sex ratio distortion; Belongs to the VCX/VCY family. | Patatin-like phospholipase domain-containing protein 4; Lipid hydrolase. | 0.700 |