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DISEASES
The following proteins in
Homo sapiens
appear to match your input.
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1) '9606.ENSP00000497217':
FOXL2 - Forkhead box protein L2; Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans- differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic [...]
[a.k.a. 668, R-HSA-2990846, R-HSA-3108232]
2) '9606.PISRT1':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
3) '9606.ENSP00000252677':
BMP15 - Bone morphogenetic protein 15; May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth.
[a.k.a. BMP15-201, Q5JST1, BC117264]
4) '9606.ENSP00000362690':
NR5A1 - Steroidogenic factor 1; Transcriptional activator. Essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. Binds phosphatidylcholine (By [...]
[a.k.a. ENST00000620110, AAB53105.1, ENST00000455734.1]
5) '9606.ENSP00000419457':
NOBOX - Homeobox protein NOBOX; Transcription factor which may play a role in oogenesis. Binds preferentially to the DNA sequences 5'-TAATTG-3', 5'-TAGTTG-3' and 5'-TAATTA-3'.
[a.k.a. ENSP00000495343, XP_016867231.1, ENST00000389325]
6) '9606.ENSP00000367942':
GDF9 - Growth/differentiation factor 9; Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells. Attenuates the suppressive effects of activin A on STAR expression and progesterone production by increasing the expression of inhibin B. It suppresses FST and FSTL3 production in granulosa-lutein cells. [...]
[a.k.a. NP_001275756.1, NM_005260, CCDS75299]
7) '9606.ENSP00000321348':
DIAPH2 - Protein diaphanous homolog 2; Could be involved in oogenesis. Involved in the regulation of endosome dynamics. Implicated in a novel signal transduction pathway, in which isoform 3 and CSK are sequentially activated by RHOD to regulate the motility of early endosomes through interactions with the actin cytoskeleton; Belongs to the formin homology family. Diaphanous subfamily.
[a.k.a. ENSP00000355369, Diaphanous related formin 2, ENST00000324765]
8) '9606.ENSP00000221496':
AMH - Muellerian-inhibiting factor; This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin.
[a.k.a. P03971, R-HSA-162582, 268]
9) '9606.ENSP00000414657':
OSR2 - Protein odd-skipped-related 2; Odd-skipped related transciption factor 2.
[a.k.a. XM_011516826, Odd-skipped related transciption factor 2, E5RH47]
10) '9606.ENSP00000290167':
WNT4 - Protein Wnt-4; Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Plays an important role in the embryonic development of the urogenital tract and the lung. Required for normal mesenchyme to epithelium transition during embryonic kidney development. Required for the formation of early epithelial renal vesicles during kidney development (By similarity). Required for normal formation of the Mullerian duct in females, and normal levels of oocytes in the ovaries. Required for normal down-regulation of 3 beta-hydroxysteroid dehydrogenase in the ovary. Req [...]
[a.k.a. Q9UJM2, XP_011539900.1, XM_011541597]
