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DISEASES
The following proteins in
Homo sapiens
appear to match your input.
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1) '9606.ENSP00000328181':
NOG - Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Essential for cartilage morphogenesis and joint formation. Inhibits chondrocyte differentiation through its interaction with GDF5 and, probably, GDF6.
[a.k.a. U31202, Q13253, R-HSA-162582]
2) '9606.ENSP00000363492':
GDF5 - Growth/differentiation factor 5; Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction. Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG. Required to prevent excessive muscle loss upo [...]
[a.k.a. R-HSA-2129379, ENST00000374372.1, CDMP1]
3) '9606.ENSP00000287020':
GDF6 - Growth/differentiation factor 6; Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal- ventral positional information in the retina and controls the formation of the retinotectal map. Required for normal formation of bones and joints in the limbs, skull, digits and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. Regulation of GDF6 expression seems to be a mechanism for evolving species-speci [...]
[a.k.a. Q6KF10, 392255, ENST00000454970]
4) '9606.C8orf37-AS1':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
5) '9606.ENSP00000371790':
FGF9 - Fibroblast growth factor 9; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors; Belongs to the heparin-binding growth factors family.
[a.k.a. NP_002001.1, R-HSA-9006925, R-HSA-5654716]
6) '9606.ENSP00000295702':
SSR2 - Translocon-associated protein subunit beta; TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins; Belongs to the TRAP-beta family.
[a.k.a. Q9BWE4, ENSG00000163479, R-HSA-1799339]
7) '9606.ENSP00000358703':
RIPPLY2 - Protein ripply2; Plays a role in somitogenesis. Required for somite segregation and establishment of rostrocaudal polarity in somites (By similarity).
[a.k.a. CCDS34493, OTTHUMG00000015117, UPI00001604A2]
8) '9606.ENSP00000342392':
MESP2 - Mesoderm posterior protein 2; Transcription factor with important role in somitogenesis. Defines the rostrocaudal patterning of the somite by participating in distinct Notch pathways. Regulates also the FGF signaling pathway. Specifies the rostral half of the somites. Generates rostro-caudal polarity of somites by down-regulating in the presumptive rostral domain DLL1, a Notch ligand. Participates in the segment border formation by activating in the anterior presomitic mesoderm LFNG, a negative regulator of DLL1-Notch signaling. Acts as a strong suppressor of Notch activity. Together w [...]
[a.k.a. bHLHc6, Q7RTU2, Mesoderm posterior protein 2]
9) '9606.ENSP00000401907':
BMPR1B - Bone morphogenetic protein receptor type-1B; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5. Positively regulates chondrocyte differentiation through GDF5 interaction.
[a.k.a. ENST00000512312.5, BMR1B_HUMAN, R-HSA-162582]
10) '9606.ENSP00000310657':
NDST2 - Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Required for the exosomal release of SDCBP, CD63 and syndecan.
[a.k.a. uc001jvk.3, NP_003626.1, HSST2]
