Your Input: | |||||
PGLYRP3 | |||||
PGLYRP4 | |||||
PGLYRP2 | |||||
BPIFB1 | |||||
RNASE7 | |||||
PRSS3 | |||||
S100A7 | |||||
DEFB1 | |||||
SLC35A2 | |||||
VSX1 |
node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DEFB1 | S100A7 | ENSP00000297439 | ENSP00000357711 | Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility. | S100 calcium binding protein A7. | 0.809 |
PGLYRP3 | PGLYRP4 | ENSP00000290722 | ENSP00000352672 | Peptidoglycan recognition protein 3; Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity; Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. | Peptidoglycan recognition protein 4; Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity. | 0.944 |
PGLYRP4 | PGLYRP3 | ENSP00000352672 | ENSP00000290722 | Peptidoglycan recognition protein 4; Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity. | Peptidoglycan recognition protein 3; Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity; Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. | 0.944 |
RNASE7 | S100A7 | ENSP00000298690 | ENSP00000357711 | Ribonuclease 7; Exhibits a potent RNase activity. Has broad-spectrum antimicrobial activity against many pathogenic microorganisms and remarkably potent activity (lethal dose of 90% < 30 nM) against a vancomycin resistant Enterococcus faecium. Causes loss of bacterial membrane integrity. Probably contributes to urinary tract sterility. Bactericidal activity is independent of RNase activity. Belongs to the pancreatic ribonuclease family. | S100 calcium binding protein A7. | 0.813 |
S100A7 | DEFB1 | ENSP00000357711 | ENSP00000297439 | S100 calcium binding protein A7. | Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility. | 0.809 |
S100A7 | RNASE7 | ENSP00000357711 | ENSP00000298690 | S100 calcium binding protein A7. | Ribonuclease 7; Exhibits a potent RNase activity. Has broad-spectrum antimicrobial activity against many pathogenic microorganisms and remarkably potent activity (lethal dose of 90% < 30 nM) against a vancomycin resistant Enterococcus faecium. Causes loss of bacterial membrane integrity. Probably contributes to urinary tract sterility. Bactericidal activity is independent of RNase activity. Belongs to the pancreatic ribonuclease family. | 0.813 |