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DISEASES
The following proteins in
Homo sapiens
appear to match your input.
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⤓ Mapping
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1) '9606.ENSP00000370119':
SMN2 - Survival of motor neuron 2, centromeric.
[a.k.a. SMN1, R-HSA-191859, ENST00000511812]
2) '9606.ENSP00000370083':
SMN1 - Survival motor neuron protein; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the ch [...]
[a.k.a. R-HSA-191859, ENST00000518504, NM_000344]
3) '9606.INE2':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
4) '9606.ENSP00000428657':
NAIP - Baculoviral IAP repeat-containing protein 1; Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at 'Asp-315' and decreasing the rate of auto proteolysis at 'Asp-330'. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor-neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor- neuron ap [...]
[a.k.a. BAD92360.1, NM_004536.2, ENST00000508794]
5) '9606.ENSP00000255078':
IGHMBP2 - DNA-binding protein SMUBP-2; 5' to 3' helicase that unwinds RNA and DNA duplices in an ATP-dependent reaction. Acts as a transcription regulator. Required for the transcriptional activation of the flounder liver-type antifreeze protein gene. Exhibits strong binding specificity to the enhancer element B of the flounder antifreeze protein gene intron. Binds to the insulin II gene RIPE3B enhancer region. May be involved in translation (By similarity). DNA-binding protein specific to 5'-phosphorylated single-stranded guanine-rich sequence related to the immunoglobulin mu chain switch regio [...]
[a.k.a. XM_011544994, Glial factor 1, XP_016873160.1]
6) '9606.ENSP00000377225':
FAM50A - Protein FAM50A; May be a DNA-binding protein or transcriptional factor.
[a.k.a. NP_004690, CH471172, ENST00000464419]
7) '9606.ENSP00000379256':
NCALD - Neurocalcin-delta; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions; Belongs to the recoverin family.
[a.k.a. ENST00000518952, ENSP00000430534, Q8IYC3]
8) '9606.ENSP00000245838':
THOC2 - THO complex subunit 2; Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap- dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cy [...]
[a.k.a. ENST00000433414, XM_017029676.1, THOC2-210]
9) '9606.ENSP00000364813':
LSM2 - U6 snRNA-associated Sm-like protein LSm2; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.
[a.k.a. ENSG00000204392, AAG33023.1, AJ245416]
10) '9606.ENSP00000229195':
CNOT2 - CCR4-NOT transcription complex subunit 2; Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4- NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may s [...]
[a.k.a. UPI0003F4818F, ENST00000549709.5, UPI00020CE26E]
