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DISEASES
The following proteins in
Homo sapiens
appear to match your input.
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1) '9606.ENSP00000493946':
RPGRIP1L - Protein fantom; Negatively regulates signaling through the G-protein coupled thromboxane A2 receptor (TBXA2R). May be involved in mechanisms like programmed cell death, craniofacial development, patterning of the limbs, and formation of the left-right axis (By similarity). Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module. Does not seem to be strictly required for ciliogenesis. Involved in establishment of planar cell polarity such as in cochlear sensory epithelium and is proposed to implicate stabilization of disheveled proteins [...]
[a.k.a. NP_001121369, ENST00000262135.9, XP_011521273]
2) '9606.ENSP00000276414':
GNRH1 - GnRH-associated peptide 1; Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.
[a.k.a. NX_P01148, R-HSA-388396, LHRH]
3) '9606.TRW-CCA7':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
4) '9606.ENSP00000430325':
TDRP - Testis development-related protein; Contributes to normal sperm motility, but not essential for male fertility; Belongs to the TDRP family.
[a.k.a. 157695, INM01, ENSP00000408126]
5) '9606.ENSP00000477587':
SRD5A2 - 3-oxo-5-alpha-steroid 4-dehydrogenase 2; Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5- alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
[a.k.a. R-HSA-556833, M74047, XP_011531374.1]
6) '9606.ENSP00000363822':
AR - Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DA [...]
[a.k.a. 4OH5, hsa:367, 4OFU]
7) '9606.ENSP00000342023':
FBXO38 - F-box only protein 38; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of PDCD1/PD-1, thereby regulating T-cells-mediated immunity. Required for anti-tumor activity of T-cells by promoting the degradation of PDCD1/PD-1; the PDCD1-mediated inhibitory pathway being exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival. May indirectly stimulate the activity of transcription factor KLF7, a regulator of neuronal differentiation, without [...]
[a.k.a. ENSP00000342023, ENST00000502571.1, ENST00000509699]
8) '9606.ENSP00000372547':
SRY - Sex-determining region Y protein; Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By similarity). In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity). Involved in different aspects of gene regulation including promoter activation or repression (By similarity). Promotes DNA bending. SRY HMG box recognizes DNA by partia [...]
[a.k.a. JQ811905, 2GZK, NM_003140.2]
9) '9606.ENSP00000221496':
AMH - Muellerian-inhibiting factor; This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin.
[a.k.a. P03971, R-HSA-162582, 268]
10) '9606.ENSP00000358903':
CYP17A1 - Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol (Probable). Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C1 [...]
[a.k.a. CYP17A1-208, 6CIR, AAA52140.1]
