Version:
12.0
Login
Register
Survey
STRING
STRING
Search
Download
Help
My Data
payload active
DISEASES
The following proteins in
Homo sapiens
appear to match your input.
Please review the list, then click 'Continue' to proceed.
<- Back
⤓ Mapping
Continue ->
1) '9606.ENSP00000379658':
ETV6 - Transcription factor ETV6; Transcriptional repressor; binds to the DNA sequence 5'- CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation; Belongs to the ETS family.
[a.k.a. 2QB0, ETV6-205, XP_011518909]
2) '9606.ENSP00000405890':
PBX1 - Pre-B-cell leukemia transcription factor 1; Binds the sequence 5'-ATCAATCAA-3'. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator by the (1;19) translocation. May have a role in steroidogenesis and, subsequently, sexual development and differentiation. Isoform PBX1b as part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhanc [...]
[a.k.a. PBX homeobox 1, R-HSA-5619507, ENSP00000405890]
3) '9606.ENSP00000300305':
RUNX1 - Runt-related transcription factor 1; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T [...]
[a.k.a. R-HSA-8939247, ENST00000479325, X90976]
4) '9606.ENSP00000436786':
KMT2A - Histone-lysine N-methyltransferase 2A; Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys- 4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic transcriptional activation. Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity. Has no [...]
[a.k.a. Q59FF2, XP_011541135.1, Lysine methyltransferase 2A]
5) '9606.ENSP00000361423':
ABL1 - Tyrosine-protein kinase ABL1; Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-bindin [...]
[a.k.a. 4J9E, 4JJB, R-HSA-5693565]
6) '9606.ENSP00000303507':
BCR - Breakpoint cluster region protein; Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form. The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound t [...]
[a.k.a. ENST00000292697, AB209991, D22S11]
7) '9606.ENSP00000378578':
AFF1 - AF4/FMR2 family member 1.
[a.k.a. XM_005263013.4, ENSP00000424483, 2LM0]
8) '9606.ENSP00000450040':
ASPG - 1-alkyl-2-acetylglycerophosphocholine esterase; Exhibits lysophospholipase, transacylase, PAF acetylhydrolase and asparaginase activities (By similarity). Can catalyze three types of transacylation reactions: (1) acyl transfer from 1-acyl-sn-glycero- 3-phosphocholine (1-acyl-GPC) to the sn-1(3) positions of glycerol and 2-acylglycerol (sn-1 to -1(3) transfer), (2) acyl transfer from 1-acyl- GPC to the sn-2 positions of 1-acyl-GPC, 1-acyl-sn-glycero-3- phosphoethanolamine (1-acyl-GPE), and other lysophospholipids (sn-1 to -2 transfer) and (3) acyl transfer from 2-acyl-GPC to the sn-1 po [...]
[a.k.a. PAF acetylhydrolase, 3.1.1.47, GPA/WT]
9) '9606.ENSP00000360329':
TTC4 - Tetratricopeptide repeat protein 4; May act as a co-chaperone for HSP90AB1. Promotes Sendai virus (SeV)-induced host cell innate immune responses.
[a.k.a. AK222562, TTC4-203, HPA041608]
10) '9606.VWA8-AS1':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
