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DISEASES
The following proteins in
Homo sapiens
appear to match your input.
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1) '9606.ENSP00000495811':
NDP - Norrin; Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt- dependent activation of FZD4, suggesting the existence of a Wnt- independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible [...]
[a.k.a. NM_000266, HGNC:7678, NP_000257.1]
2) '9606.ENSP00000222747':
TSPAN12 - Tetraspanin-12; Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt- dependent activation of FZD4, suggesting the existence of a Wnt- independent signaling that also [...]
[a.k.a. TSPAN12-202, uc003vjk.4, ENST00000450414]
3) '9606.ENSP00000434034':
FZD4 - Frizzled-4; Receptor for Wnt proteins. Most frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes. Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP) (By similarity). In retina, it can be activated by Wnt protein-binding and also by Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accu [...]
[a.k.a. frizzled homolog 4 (Drosophila), FzE4, frizzled (Drosophila) homolog 4]
4) '9606.ENSP00000267163':
RB1 - Retinoblastoma-associated protein; Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransfer [...]
[a.k.a. R-HSA-2559584, R-HSA-69278, M27857]
5) '9606.ENSP00000309606':
ZNF408 - Zinc finger protein 408; May be involved in transcriptional regulation.
[a.k.a. Q9H9D4, HPA017892, NP_001171680.1]
6) '9606.ENSP00000369320':
RS1 - Retinoschisin; Binds negatively charged membrane lipids, such as phosphatidylserine and phosphoinositides (By similarity). May play a role in cell-cell adhesion processes in the retina, via homomeric interaction between octamers present on the surface of two neighboring cells. Required for normal structure and function of the retina.
[a.k.a. AF018962, RS, ENST00000325561]
7) '9606.ENSP00000356319':
KIF14 - Kinesin-like protein KIF14; Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis. During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively. Regulates cell growth through regulation of cell cycle progression and cytokinesis. During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic [...]
[a.k.a. XP_011508534.1, R-HSA-162582, XP_016858494]
8) '9606.ENSP00000356150':
MDM4 - Protein Mdm4; Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions; Belongs to the MDM2/MDM4 family.
[a.k.a. ENST00000462012, 3LBJ, MDM4, p53 regulator]
9) '9606.NDP-AS1':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
10) '9606.ENSP00000264376':
CRYGD - Gamma-crystallin D; Crystallins are the dominant structural components of the vertebrate eye lens.
[a.k.a. hsa:1421, OMIM:123690, uc002vcn.5]
