Your Input: | |||||
TMC8 | |||||
CARMIL2 | |||||
TMC6 | |||||
DOCK8 | |||||
CYB561A3 | |||||
CIB1 | |||||
IFNA1 | |||||
CD4 | |||||
GATA2 | |||||
IFNA2 |
node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CD4 | IFNA1 | ENSP00000011653 | ENSP00000276927 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | Interferon alpha-1/13; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs to the alpha/beta interferon family. | 0.887 |
CD4 | IFNA2 | ENSP00000011653 | ENSP00000369554 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | Interferon alpha-2; Produced by macrophages, IFN-alpha have antiviral activities. | 0.788 |
CIB1 | TMC8 | ENSP00000479860 | ENSP00000325561 | Calcium and integrin-binding protein 1; Calcium-binding protein that plays a role in the regulation of numerous cellular processes, such as cell differentiation, cell division, cell proliferation, cell migration, thrombosis, angiogenesis, cardiac hypertrophy and apoptosis. Involved in bone marrow megakaryocyte differentiation by negatively regulating thrombopoietin- mediated signaling pathway. Participates in the endomitotic cell cycle of megakaryocyte, a form of mitosis in which both karyokinesis and cytokinesis are interrupted. Plays a role in integrin signaling by negatively regulat [...] | Transmembrane channel-like protein 8; Probable ion channel; Belongs to the TMC family. | 0.717 |
IFNA1 | CD4 | ENSP00000276927 | ENSP00000011653 | Interferon alpha-1/13; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs to the alpha/beta interferon family. | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | 0.887 |
IFNA2 | CD4 | ENSP00000369554 | ENSP00000011653 | Interferon alpha-2; Produced by macrophages, IFN-alpha have antiviral activities. | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | 0.788 |
TMC6 | TMC8 | ENSP00000465261 | ENSP00000325561 | Transmembrane channel-like protein 6; Probable ion channel; Belongs to the TMC family. | Transmembrane channel-like protein 8; Probable ion channel; Belongs to the TMC family. | 0.740 |
TMC8 | CIB1 | ENSP00000325561 | ENSP00000479860 | Transmembrane channel-like protein 8; Probable ion channel; Belongs to the TMC family. | Calcium and integrin-binding protein 1; Calcium-binding protein that plays a role in the regulation of numerous cellular processes, such as cell differentiation, cell division, cell proliferation, cell migration, thrombosis, angiogenesis, cardiac hypertrophy and apoptosis. Involved in bone marrow megakaryocyte differentiation by negatively regulating thrombopoietin- mediated signaling pathway. Participates in the endomitotic cell cycle of megakaryocyte, a form of mitosis in which both karyokinesis and cytokinesis are interrupted. Plays a role in integrin signaling by negatively regulat [...] | 0.717 |
TMC8 | TMC6 | ENSP00000325561 | ENSP00000465261 | Transmembrane channel-like protein 8; Probable ion channel; Belongs to the TMC family. | Transmembrane channel-like protein 6; Probable ion channel; Belongs to the TMC family. | 0.740 |