Your Input: | |||||
PRSS57 | |||||
SH2D3A | |||||
SH2D3C | |||||
MXRA8 | |||||
ERF | |||||
LDLRAD3 | |||||
ERVW-1 | |||||
TCF23 | |||||
VPS50 | |||||
FURIN |
node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ERVW-1 | FURIN | ENSP00000419945 | ENSP00000483552 | Transmembrane protein; This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. May induce fusion through binding of SLC1A4 and SLC1A5. | Furin; Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif. Mediates processing of TGFB1, an essential step in TGF-beta-1 activation. (Microbial infection) Required for H7N1 and H5N1 influenza virus infection probably by cleaving hemagglutinin. | 0.756 |
FURIN | ERVW-1 | ENSP00000483552 | ENSP00000419945 | Furin; Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif. Mediates processing of TGFB1, an essential step in TGF-beta-1 activation. (Microbial infection) Required for H7N1 and H5N1 influenza virus infection probably by cleaving hemagglutinin. | Transmembrane protein; This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. May induce fusion through binding of SLC1A4 and SLC1A5. | 0.756 |
PRSS57 | SH2D3A | ENSP00000482358 | ENSP00000245908 | Serine protease 57; Serine protease that cleaves preferentially after Arg residues. Can also cleave after citrulline (deimidated arginine) and methylarginine residues ; Belongs to the peptidase S1 family. | SH2 domain-containing protein 3A; May play a role in JNK activation. | 0.997 |
PRSS57 | SH2D3C | ENSP00000482358 | ENSP00000317817 | Serine protease 57; Serine protease that cleaves preferentially after Arg residues. Can also cleave after citrulline (deimidated arginine) and methylarginine residues ; Belongs to the peptidase S1 family. | SH2 domain-containing protein 3C; Eph receptor-binding protein which may be a positive regulator of TCR signaling. Binding to BCAR1 is required to induce membrane ruffling and promote EGF-dependent cell migration (By similarity). | 0.998 |
SH2D3A | PRSS57 | ENSP00000245908 | ENSP00000482358 | SH2 domain-containing protein 3A; May play a role in JNK activation. | Serine protease 57; Serine protease that cleaves preferentially after Arg residues. Can also cleave after citrulline (deimidated arginine) and methylarginine residues ; Belongs to the peptidase S1 family. | 0.997 |
SH2D3A | SH2D3C | ENSP00000245908 | ENSP00000317817 | SH2 domain-containing protein 3A; May play a role in JNK activation. | SH2 domain-containing protein 3C; Eph receptor-binding protein which may be a positive regulator of TCR signaling. Binding to BCAR1 is required to induce membrane ruffling and promote EGF-dependent cell migration (By similarity). | 0.931 |
SH2D3C | PRSS57 | ENSP00000317817 | ENSP00000482358 | SH2 domain-containing protein 3C; Eph receptor-binding protein which may be a positive regulator of TCR signaling. Binding to BCAR1 is required to induce membrane ruffling and promote EGF-dependent cell migration (By similarity). | Serine protease 57; Serine protease that cleaves preferentially after Arg residues. Can also cleave after citrulline (deimidated arginine) and methylarginine residues ; Belongs to the peptidase S1 family. | 0.998 |
SH2D3C | SH2D3A | ENSP00000317817 | ENSP00000245908 | SH2 domain-containing protein 3C; Eph receptor-binding protein which may be a positive regulator of TCR signaling. Binding to BCAR1 is required to induce membrane ruffling and promote EGF-dependent cell migration (By similarity). | SH2 domain-containing protein 3A; May play a role in JNK activation. | 0.931 |