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DISEASES
The following proteins in
Homo sapiens
appear to match your input.
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1) '9606.ENSP00000372313':
MSLN - Megakaryocyte-potentiating factor; Membrane-anchored forms may play a role in cellular adhesion; Belongs to the mesothelin family.
[a.k.a. BC009272, Mesothelin, mesothelin]
2) '9606.ENSP00000263341':
IL1B - Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells.
[a.k.a. C9JSC2, ENST00000432018, ENST00000418817]
3) '9606.ENSP00000307508':
CALB2 - Calretinin; Calretinin is a calcium-binding protein which is abundant in auditory neurons; Belongs to the calbindin family.
[a.k.a. AK291096, ENST00000302628, ENST00000562305]
4) '9606.hsa-miR-625-3p':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
5) '9606.ENSP00000436812':
MUC5B - Mucin-5B; Gel-forming mucin that is thought to contribute to the lubricating and viscoelastic properties of whole saliva and cervical mucus.
[a.k.a. ENST00000535652, NX_Q9HC84, O15494]
6) '9606.ENSP00000433138':
CASP1 - Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]
[a.k.a. 3.4.22.36, NM_033294.3, P29466]
7) '9606.ENSP00000337383':
NLRP3 - NACHT, LRR and PYD domains-containing protein 3; As the sensor component of the NLRP3 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP3, PYCARD and CASP1 (and possibly CASP4 and CASP5). Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP3 inflammasome is also required for HMGB1 secretion. The active cytokin [...]
[a.k.a. NM_004895.4, ENST00000532083, XM_024452862.1]
8) '9606.ENSP00000378058':
EFEMP1 - EGF-containing fibulin-like extracellular matrix protein 1; Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth; Belongs to the fibulin family.
[a.k.a. R-HSA-2129379, XM_024452756, ENST00000394554]
9) '9606.ENSP00000385428':
NLRC4 - NLR family CARD domain-containing protein 4; Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria (By similarity).
[a.k.a. NP_001186068.1, NM_001199138.2, NM_001199139.1]
10) '9606.ENSP00000221930':
TGFB1 - Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...]
[a.k.a. R-HSA-2129379, R-HSA-170834, ENST00000221930.5]
