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DISEASES
The following proteins in
Homo sapiens
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1) '9606.ENSP00000294489':
PDPN - 29kDa cytosolic podoplanin intracellular domain; Mediates effects on cell migration and adhesion through its different partners. During development plays a role in blood and lymphatic vessels separation by binding CLEC1B, triggering CLEC1B activation in platelets and leading to platelet activation and/or aggregation. Interaction with CD9, on the contrary, attenuates platelet aggregation induced by PDPN. Through MSN or EZR interaction promotes epithelial- mesenchymal transition (EMT) leading to ERZ phosphorylation and triggering RHOA activation leading to cell migration increase and inv [...]
[a.k.a. CCDS30602.1, Glycoprotein 36, NP_001006626.1]
2) '9606.ENSP00000425493':
CAGE1 - Cancer-associated gene 1 protein; Cancer antigen 1.
[a.k.a. ENSP00000423789, Q8TC20, NP_001164163]
3) '9606.ENSP00000373706':
DIAPH1 - Protein diaphanous homolog 1; Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers (By similarity). Binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization (By similarity). Required for cytokinesis, and transcriptional activation of the serum response factor (By similarity). DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics (By similarity). Functions as a scaffold protein for MAPRE1 and APC to stabilize microtubules [...]
[a.k.a. XM_024454385.1, H7C2W8, DIAPH1-201]
4) '9606.ENSP00000395929':
NSD1 - Histone-lysine N-methyltransferase, H3 lysine-36 specific; Histone methyltransferase that dimethylates Lys-36 of histone H3 (H3K36me2). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context.
[a.k.a. ENSP00000354310, ENSP00000426428, ENST00000508896.5]
5) '9606.ENSP00000372351':
NSD2 - Histone-lysine N-methyltransferase NSD2; Histone methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity forming trimethylated 'Lys-27' (H3K27me3). Isoform 2 may act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment.
[a.k.a. ENST00000515806.1, R-HSA-5693565, R-HSA-69620]
6) '9606.ENSP00000314992':
RRH - Visual pigment-like receptor peropsin; May play a role in rpe physiology either by detecting light directly or by monitoring the concentration of retinoids or other photoreceptor-derived compounds.
[a.k.a. HGNC:10450, R-HSA-388396, NP_006574.1]
7) '9606.hsa-miR-195-5p':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
8) '9606.hsa-miR-29c-3p':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
9) '9606.ENSP00000418525':
MME - Neprilysin; Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers. Belongs to the peptidase M13 family.
[a.k.a. CALLA, MME-213, ENST00000462837.5]
10) '9606.ENSP00000420270':
UHMK1 - Serine/threonine-protein kinase Kist; Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA (By similarity).
[a.k.a. ENST00000538489, Q8TAS1, ENST00000323192]
