Your Input: | |||||
VPS13A | |||||
VPS13D | |||||
VPS13B | |||||
VPS13C | |||||
JPH3 | |||||
XK | |||||
XKRX | |||||
PANK2 | |||||
VAPA | |||||
LYN |
node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
JPH3 | VPS13A | ENSP00000284262 | ENSP00000353422 | Junctophilin-3; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH3 is brain- specific and appears to have an active role in certain neurons involved in motor coordination and memory. | Vacuolar protein sorting-associated protein 13A; May play a role in the control of protein cycling through the trans-Golgi network to early and late endosomes, lysosomes and plasma membrane. | 0.827 |
VAPA | VPS13A | ENSP00000345656 | ENSP00000353422 | Vesicle-associated membrane protein-associated protein A; Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With OSBPL3, may regulate ER morphology. May play a role in vesicle trafficking. | Vacuolar protein sorting-associated protein 13A; May play a role in the control of protein cycling through the trans-Golgi network to early and late endosomes, lysosomes and plasma membrane. | 0.804 |
VPS13A | JPH3 | ENSP00000353422 | ENSP00000284262 | Vacuolar protein sorting-associated protein 13A; May play a role in the control of protein cycling through the trans-Golgi network to early and late endosomes, lysosomes and plasma membrane. | Junctophilin-3; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH3 is brain- specific and appears to have an active role in certain neurons involved in motor coordination and memory. | 0.827 |
VPS13A | VAPA | ENSP00000353422 | ENSP00000345656 | Vacuolar protein sorting-associated protein 13A; May play a role in the control of protein cycling through the trans-Golgi network to early and late endosomes, lysosomes and plasma membrane. | Vesicle-associated membrane protein-associated protein A; Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With OSBPL3, may regulate ER morphology. May play a role in vesicle trafficking. | 0.804 |
VPS13A | XK | ENSP00000353422 | ENSP00000367879 | Vacuolar protein sorting-associated protein 13A; May play a role in the control of protein cycling through the trans-Golgi network to early and late endosomes, lysosomes and plasma membrane. | Membrane transport protein XK; May be involved in sodium-dependent transport of neutral amino acids or oligopeptides. | 0.954 |
XK | VPS13A | ENSP00000367879 | ENSP00000353422 | Membrane transport protein XK; May be involved in sodium-dependent transport of neutral amino acids or oligopeptides. | Vacuolar protein sorting-associated protein 13A; May play a role in the control of protein cycling through the trans-Golgi network to early and late endosomes, lysosomes and plasma membrane. | 0.954 |