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DISEASES
The following proteins in
Homo sapiens
appear to match your input.
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1) '9606.ENSP00000420525':
TFR2 - Transferrin receptor protein 2; Mediates cellular uptake of transferrin-bound iron in a non- iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation; Belongs to the peptidase M28 family. M28B subfamily.
[a.k.a. ENST00000462090, URS0000E9F5C9, TFR2-210]
2) '9606.ENSP00000337014':
HJV - Hemojuvelin; Acts as a bone morphogenetic protein (BMP) coreceptor. Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis. Belongs to the repulsive guidance molecule (RGM) family.
[a.k.a. ENSP00000411863, ENSP00000489347, HJV-202]
3) '9606.ENSP00000417404':
HFE - Hereditary hemochromatosis protein; Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin.
[a.k.a. CH471087, HFE-214, ENST00000349999]
4) '9606.ENSP00000471894':
HAMP - Hepcidin-20; Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes. Belongs to the hepcidin family.
[a.k.a. CHEMBL3989381, NP_066998.1, PLTR]
5) '9606.ENSP00000261024':
SLC40A1 - Solute carrier family 40 member 1; May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin); Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.
[a.k.a. SLC11A3, R-HSA-425410, AF171087]
6) '9606.ENSP00000378364':
SLC11A2 - Natural resistance-associated macrophage protein 2; Important in metal transport, in particular iron. Can also transport manganese, cobalt, cadmium, nickel, vanadium and lead. Involved in apical iron uptake into duodenal enterocytes. Involved in iron transport from acidified endosomes into the cytoplasm of erythroid precursor cells. May play an important role in hepatic iron accumulation and tissue iron distribution. May serve to import iron into the mitochondria. Belongs to the NRAMP family.
[a.k.a. XP_005268969.1, R-HSA-425410, UPI00001FC234]
7) '9606.ENSP00000299320':
C16orf71 - Uncharacterized protein C16orf71; Chromosome 16 open reading frame 71.
[a.k.a. ENST00000586256.1, BC035024, ENST00000619274]
8) '9606.ENSP00000376197':
TFRC - Transferrin receptor protein 1, serum form; Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with tra [...]
[a.k.a. TFRC-207, 7037, TFRC-206]
9) '9606.C9orf163':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
10) '9606.ENSP00000370635':
SLC39A14 - Zinc transporter ZIP14; Broad-scope metal ion transporter with a preference for zinc uptake. Also mediates cellular uptake of nontransferrin-bound iron.
[a.k.a. ENST00000518348, R-HSA-425410, NM_001351657]
