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PEX6 | |||||
PEX12 | |||||
PEX26 | |||||
PEX10 | |||||
PEX13 | |||||
PEX2 | |||||
PEX5 | |||||
PEX16 | |||||
PEX1 | |||||
PEX7 |
node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PEX1 | PEX10 | ENSP00000248633 | ENSP00000288774 | Peroxisome biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes. | 0.966 |
PEX1 | PEX12 | ENSP00000248633 | ENSP00000482609 | Peroxisome biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. | Peroxisome assembly protein 12; Required for protein import into peroxisomes. | 0.965 |
PEX1 | PEX13 | ENSP00000248633 | ENSP00000295030 | Peroxisome biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. | Peroxisomal membrane protein PEX13; Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins. | 0.969 |
PEX1 | PEX16 | ENSP00000248633 | ENSP00000241041 | Peroxisome biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. | Peroxisomal membrane protein PEX16; Required for peroxisome membrane biogenesis. May play a role in early stages of peroxisome assembly. Can recruit other peroxisomal proteins, such as PEX3 and PMP34, to de novo peroxisomes derived from the endoplasmic reticulum (ER). May function as receptor for PEX3. Belongs to the peroxin-16 family. | 0.855 |
PEX1 | PEX2 | ENSP00000248633 | ENSP00000349543 | Peroxisome biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. | Peroxisome biogenesis factor 2; Somewhat implicated in the biogenesis of peroxisomes; Belongs to the pex2/pex10/pex12 family. | 0.947 |
PEX1 | PEX26 | ENSP00000248633 | ENSP00000331106 | Peroxisome biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. | Peroxisome assembly protein 26; Probably required for protein import into peroxisomes. Anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Involved in the import of catalase and proteins containing a PTS2 target sequence, but not in import of proteins with a PTS1 target sequence. | 0.989 |
PEX1 | PEX5 | ENSP00000248633 | ENSP00000391601 | Peroxisome biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. | Peroxisomal targeting signal 1 receptor; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. | 0.977 |
PEX1 | PEX6 | ENSP00000248633 | ENSP00000303511 | Peroxisome biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. | Peroxisome assembly factor 2; Involved in peroxisome biosynthesis. Required for stability of the PTS1 receptor. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. | 0.999 |
PEX1 | PEX7 | ENSP00000248633 | ENSP00000315680 | Peroxisome biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. | Peroxisomal targeting signal 2 receptor; Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import. Belongs to the WD repeat peroxin-7 family. | 0.938 |
PEX10 | PEX1 | ENSP00000288774 | ENSP00000248633 | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes. | Peroxisome biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. | 0.966 |
PEX10 | PEX12 | ENSP00000288774 | ENSP00000482609 | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes. | Peroxisome assembly protein 12; Required for protein import into peroxisomes. | 0.999 |
PEX10 | PEX13 | ENSP00000288774 | ENSP00000295030 | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes. | Peroxisomal membrane protein PEX13; Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins. | 0.998 |
PEX10 | PEX16 | ENSP00000288774 | ENSP00000241041 | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes. | Peroxisomal membrane protein PEX16; Required for peroxisome membrane biogenesis. May play a role in early stages of peroxisome assembly. Can recruit other peroxisomal proteins, such as PEX3 and PMP34, to de novo peroxisomes derived from the endoplasmic reticulum (ER). May function as receptor for PEX3. Belongs to the peroxin-16 family. | 0.962 |
PEX10 | PEX2 | ENSP00000288774 | ENSP00000349543 | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes. | Peroxisome biogenesis factor 2; Somewhat implicated in the biogenesis of peroxisomes; Belongs to the pex2/pex10/pex12 family. | 0.999 |
PEX10 | PEX26 | ENSP00000288774 | ENSP00000331106 | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes. | Peroxisome assembly protein 26; Probably required for protein import into peroxisomes. Anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Involved in the import of catalase and proteins containing a PTS2 target sequence, but not in import of proteins with a PTS1 target sequence. | 0.970 |
PEX10 | PEX5 | ENSP00000288774 | ENSP00000391601 | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes. | Peroxisomal targeting signal 1 receptor; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. | 0.995 |
PEX10 | PEX6 | ENSP00000288774 | ENSP00000303511 | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes. | Peroxisome assembly factor 2; Involved in peroxisome biosynthesis. Required for stability of the PTS1 receptor. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. | 0.989 |
PEX10 | PEX7 | ENSP00000288774 | ENSP00000315680 | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes. | Peroxisomal targeting signal 2 receptor; Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import. Belongs to the WD repeat peroxin-7 family. | 0.985 |
PEX12 | PEX1 | ENSP00000482609 | ENSP00000248633 | Peroxisome assembly protein 12; Required for protein import into peroxisomes. | Peroxisome biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. | 0.965 |
PEX12 | PEX10 | ENSP00000482609 | ENSP00000288774 | Peroxisome assembly protein 12; Required for protein import into peroxisomes. | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes. | 0.999 |